On February 10, Professor Yu Xiao's team, Professor Sun Jinpeng's team, Professor Shao Zhenhua's team of West China Hospital of Sichuan University, Professor Zhang Lei's team of Xi'an Jiaotong University, and Professor Du Yang's team of Chinese University of Hong Kong (Shenzhen) jointly published an online publication entitled "liver recognition and allosteric regulation of DRD1 GS signaling" in cell magazine It is the first time to analyze the structure of dopamine receptor DRD1 GS complex and explain the molecular mechanism of DRD1 ligand recognition, allosteric regulation, and G protein coupling. Xiao Peng, research fellow and master of Shandong University School of basic medicine Zhong Yanni, Yan Wei, associate professor of Sichuan University, Gou Lu, a doctoral student of Xi'an Jiaotong University, and Kong Liangliang, National Center for protein (Shanghai) are the co-first authors; Yu Xiao, sun Jinpeng, Shao Zhenhua, Zhang Lei and Du Yang are the co-corresponding authors.
Yu Xiao's research team has long been concerned about GPCR in metabolic physiology and pathophysiology. In the past studies, we have clarified the regulatory role of crhr2 and adrenoceptors in islet circuits and homeostasis (J Clin invest. 2017, Jun 30; 127 (7): 2631) (diabetes. 2014 Sep; 57 (9): 1899) (diabetes. 2015 Feb; 58 (2): 324); revealed the precise regulation mechanism of cck1r preferred pathway on islet function (Br J pharmaceutical. 2015 Nov; 172 (21): 5050); discovered the regulation of adhesion receptor on water and salt metabolism (eLife. 2018 Feb 2; 7: e33432.); clarified the unique mechanism of bile acid receptor-ligand recognition and activation (nature. 2020nov; 7: e33432.); 587 (7834): 499-504.) and so on. In China, together with Professor Hu Huili and Professor Sun Jinpeng of basic medical college, they have realized the proliferation of islets in vitro for the first time (cell discovery 2020).
The above research is supported by the National Science Fund for Distinguished Young Scholars, National Science Fund for Distinguished Young Scholars, and National Natural Science Foundation of China.
Article link:https://www.cell.com/cell/fulltext/S0092-8674 (21)00071-4
