Recently, Professor Gao Chengjiang’s team of Basic Medical College published a research paper titled“The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR” online in Redox Biology (CAS 1, IF:11.799). Zeng Shenglan, a graduate student of basic medical college, is the first author of this paper, Professors Huiqing Liu and Chengjiang Gao are the co-corresponding authors of this paper. Shandong University is the first unit and the corresponding unit.

In this study, this study found for the first time that the E3 ubiquitin ligase TRIM31 binds to TIGAR through its B-box region and promotes TIGAR's ubiquitination proteasome degradation. In the pathological process of cerebral ischemia, TRIM31 can negatively regulate TIGAR protein level, inhibit pentose phosphate flux, slow down the process of eliminating excess ROS in the brain, and aggravate mitochondrial dysfunction, thus leading to ischemic brain injury. These results suggest that TRIM31 plays a key role in the pathological process of ischemic brain injury by regulating TIGAR protein level, which may be an important therapeutic target for patients with ischemic stroke.

Paper link: https://doi.org/10.1016/j.redox.2021.102058