Recently, Professor Gao Chengjiang's team of basic medical college has made new progress in the research of antifungal immune regulation, and published a research paper entitled "trim31 facilities K27 linked polyimmunization of Syk to regulate antifungal immunity" in the form of article in the Journal of signal transmission and targeted therapy (zone 1, Chinese Academy of Sciences, if: 18.187). Wang Xueer, a doctoral student of the school of basic medicine of Shandong University, and Zhang Honghai, a doctoral student of the school of basic medicine of Shandong University, are the co first authors of this paper, and Professor Gao Chengjiang is the corresponding author of this paper. Shandong University is the first author unit and the only corresponding author unit.

By screening the deubiquitination enzymes targeting CARD9, we found that OTUD1 could rescind the polyubiquitin chain linked to THE K33 position of CARD9 and promote the assembly of CBM complex, thereby enhancing the activation of NF-κB and MAPK signaling pathways downstream. Loss of OTUD1 reduces card9-mediated signaling, decreases expression of pro-inflammatory cytokines and chemokines, and makes OTUD1-knockout mice more susceptible to candida albicans infection (J Immunol2021;206:1832-1843).These results enrich the research of antifungal natural immune signal transduction and provide a new theoretical basis for antifungal clinical research and drug development.

Paper link: https://doi.org/10.1038/s41392-021-00711-3