Recently, Professor Ma Chunhong’s team published an article in the Journal for ImmunoTherapy of Cancer (the first area of the Chinese Academy of Sciences, IF=13.75), titled “Switch receptor T3/28 improves long-term persistence and anti-tumor efficacy of CAR-T cells ". The first author, Songbai Zhao, is a doctoral student of the School of Basic Medical Sciences and Professor Lifen Gao of the School of Basic Medical Sciences is the corresponding author. Shandong University is the first author unit and the only corresponding author unit. The microfluidic technology for the detection of cytokines in this study was strongly supported by Professor Han Lin from the Institute of Oceanography of Shandong University.

Chimeric antigen receptor-modified T cell (CAR-T) technology is a new type of cellular immunotherapy, which has become one of the important tumor immunotherapy methods. The team modified CAR to improve the killing ability of CAR-T cells and improve the rapid depletion of CAR-T cells. This study revealed the impact of T3/28 molecular switch on CAR-T cells and provided a new strategy for the optimization of CAR-T cells.