Recently, Professor Han Bing's research team on parasite pathogenesis and control technology held a conference in Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences) (TOP journal of CAS 1, five-year IF: 10.8) published a direct submission entitled "Microsporidian EnP1 alters host cell H2B monoubiquitination and prevents ferroptosis". facilitating microsporidia survival". This study elucidated the molecular mechanism of microsporidia encephalitis by secreting the effector protein EnP1 to target the nucleus of the host cell and promote the proliferation of pathogens during host infection. Guan Jingyu, a doctoral student from the School of Basic Medical Sciences of Shandong University, is the first author of this paper, and Professor Han Bing, assistant researcher Qu Hongnan, Professor Zhou Huaiyu, and Professor Louis Weiss of the Albert Einstein College of Medicine are the corresponding authors of this paper. Shandong University is the first author and corresponding author of this study.

At present, the pathogenic mechanism and control strategies of Microsporidia are still poorly understood, so it is of great significance to study the interaction mechanism between Microsporidia and the host for the prevention and control of Microsporidiasis. This study revealed the molecular mechanism of epigenetic regulation of the host by Microsporidia encephalitis through the secretion of effector protein EnP1, which provides a potential target for the treatment of microsporidiosis in the future. Professor Han Bing's team has long been committed to the study of the pathogenic mechanism and prevention and control strategies of zoonotic parasitic diseases (such as microsporidiosis and toxoplasmosis), and has analyzed for the first time in the field of microsporidia research on the molecular mechanism of microsporidia pole tube infection of host cells, as well as the molecular mechanism of the interaction between microsporidia spore protoplasm and host mitochondria Reviews and academic journals such as Parasites & Vectors. This research was supported by the National Natural Science Foundation of China and the Qilu Young Scholars Talent Program of Shandong University.