The intensification of global aging has led to a sharp increase in the incidence of aging-related diseases. Among them, the kidney is one of the organs that undergoes the most obvious changes during human aging. Aging renders intrinsic renal cells, such as glomerular endothelial cells, podocytes, and renal tubular epithelial cells, susceptible to damaging factors, and induces senescent phenotypes in renal cells, which feedback to accelerate the progression of kidney diseases. It is one of the major risk factors for the occurrence and development of various kidney diseases. G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptor proteins in the human body, playing crucial roles in cellular signal transduction and the regulation of physiological functions. They have attracted increasing attention, especially in the field of anti-aging research. Recently, Professor Yi Fan’s team and Professor Sun Jinpeng’s team from Shandong University have conducted joint research and achieved a series of new advances in the field of renal aging. Multiple research papers have been published in international authoritative journals such as Circulation Research, Journal of the American Society of Nephrology, and Kidney International, each receiving featured recommendations in the corresponding issues and accompanying editorial commentaries, which have garnered widespread attention and high recognition from the international academic community.