Zhen LIU-School of Basic Medical Sciences/Biomedical Sciences (BMS), Shandong University

Faculty

Department of Anatomy & Histoembryology

Zhen LIU

I. GENERAL INFORMATION

LAST NAME: Liu

FIRST NAME: Zhen

DEGREES: M.D., Ph.D.

SEX: Female

NATION: Hui

YEAR OF BIRTH: 1981

MAILING ADDRESS: Department of Anatomy

Shandong University School of Basic Medical Sciences

44 Wen Hua Xi Road

Jinan, Shandong Province 250012

P. R. China

E-MAIL: zhen@sdu.edu.cn

MEMBERSHIP IN PROFESSIONAL SOCIETIES:Chinese Society for Anatomical Sciences (CSAS), Shandong Society for Anatomical Sciences (SSAS)

II. EDUCATION

Aug 1998-July 2003 Medical student for MD, Shandong University School of Medicine, Shandong Province, P. R. China

Aug 2003-June 2008 Postgraduate student for PhD, Department of Anatomy, Shandong University School of Medicine, Shandong Province, P. R. China

III. EMPLOYMENT

Sep 2007-Mar 2008 Visiting Scholar in the Medical University of South Carolina, Charleston, SC 29425 USA

Sep 2008-May 2010 Postdoctor fellow, Deparment of Neurology, Shandong University Qilu Hospital

July 2008-Mar 2011 Lecturer, Department of Anatomy, Shandong University School of 1

Medicine

Apr 2011-Aug 2013 Lecturer, Supervisor for Master Degree Postgraduate student, Department of Anatomy, Shandong University School of Medicine

Sep 2013-Dec 2016 Associate professor, Supervisor for Master Degree Postgraduate student, Department of Anatomy, Shandong University School of Medicine

Jan 2017- Associate professor, Supervisor for Master Degree Postgraduate student, Department of Anatomy, Histology and Embryology, Shandong University School of Basic Medical Sciences

IV. TEACHING ACTIVITIES

Undergraduate Medicine Lectures:

2008-present

Systematic Anatomy (Chinese and English) (two/yr) Med I students

Regional Anatomy (Chinese and English) (two/yr) Med II/ III students

Human Anatomy (English) (two/3yrs) International Med I students

Graduate Student Lectures:

2008-2014 Clinical Anatomy of Thoracic Region (Chinese and English) (one/yr)

2011-present Clinical Neuroanatomy (English) (one/yr)

2000-present Culturing Nerve Cells (one/yr)

Massive Open Online Courses

Regional Anatomy, Principal speaker

Systematic Anatomy, Principal speaker

V. TEACHING RESEARCH

1. 2015, The first MOOC curriculum reform of Shandong University: Regional Anatomy (2nd investigator)

2. 2015, The first “flipped classroom” teaching method reform experimentation (3rd investigator)

3. 2017, Undergraduate demonstration classroom: Regional Anatomy (2nd investigator)

4. 2017, Undergraduate demonstration classroom: Systematic Anatomy (4th investigator)

5. 2017, National quality online open Courses: Regional Anatomy (Principal speaker)

6. 2017, National quality online open Courses: Systematic Anatomy (Principal speaker)

7. 2018, Reform of clinical application-oriented information-based teaching of regional anatomy, Undergraduate teaching reform and research project of Cheeloo Colleges of Medicine of Shandong University (1st investigator)

8. 2019, Practical application-oriented pluralistic teaching reform of regional anatomy, Shandong University (1st investigator)

VI. RESEARCH SUPERVISION

Graduate Students for MS:

1. Cheng Chen, 2011-2014

2. Bai Xue, 2012-2015

3. Yin Yiting, 2015-2018

VII. RESEARCH INTERESTS

1. Pathogenesis of neuropathy

2. Primary transmission and pain

VIII.PUBLISHED BOOKS

1. 《Regional Anatomy》, Editor, Beijing: China Medical Science and Technology Press, 2016.12, ISBN ISBN978-7-5067-8199-2.

2. 《Regional Anatomy》, 3rd Edition, Editor, Beijing: Higher Education Press, 2014.6, ISBN 978-7-04-039714-7.

3. 《Systematic Anatomical Guide》, Associate editor in chief, Shanghai, Tongji University Press, 2014.10, ISBN 978-7-5608-5606-3.

4. 《Regional Anatomical Guide》, Associate editor in chief, Shanghai, Tongji University Press, 2014.03, ISBN 978-7-5608-5413-7.

5. 《Medical morphology experiment》, 2nd Edition, Editor, Science and Technology Press, 2013.10, ISBN 978-7-0303-8286-3.

IX. RESEARCH FUNDINGS AS PRINCIPAL INVESTIGATOR

1. Effects and mechanisms of galanin on inflammatory pain processing (No.81000517). The National Natural Science Foundation of China. 2011-2013.

2. Galanin and its receptors on the diabetic neuropathy pain (ZR2011HQ011). The Natural Science Foundation of Shandong Province of China. 2011-2014.

3. Effects and mechanisms of galanin on norepinephrine induced pain (No.20090131120013). The Foundation for the Doctoral Program New Teacher of State Education Ministry of China. 2010-2012.

4. New therapeutic targets on chronic inflammatory pain (No.200904501203). China Postdoctoral Science Foundation. 2009-2012.

IX. SELECTED PUBLICATIONS IN REFEREED JOURNALS

1. Liu Y, Li J, Li H, Shang Y, Guo Y, Li Z, Liu Z#. AMPK activation in dorsal root ganglion suppresses mTOR/p70S6K signalling and alleviates painful radiculopathies in lumbar disc herniation rat model. Spine, 2019, 44 (15): E865-E872.

2. Yu T, Li L, Liu H, Li H, Liu Z, Li Z. KCNQ2/3/5 channels in dorsal root ganglion neurons can be therapeutic targets of neuropathicpain in diabetic rats. Mol Pain, 2018, 14: 1744806918793229.

3. Ding Y, Li J, Liu Z, Liu H, Li H, Li Z. IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusionbalance. Sci Rep, 2017, 7: 43949.

4. Bai X, Chen T, Gao Y, Li H, Li Z, Liu Z#. The protective effects of insulin-like growth factor-1 on neurochemical phenotypes of dorsal rootganglion neurons with BDE-209-induced neurotoxicity in vitro. Toxicol Ind Health, 2017, 33 (3): 250-264.

5. Ding Y, Li J, Liu Z, Liu H, Li H, Li Z. IGF-1 potentiates sensory innervation signalling by modulating the mitochondrial fission/fusionbalance. Sci Rep, 2017, 7:43949.

6. Chen C, Bai X, Bi Y, Liu G, Li H, Liu Z, Liu H. Insulin-like growth factor-1 attenuates apoptosis and protects neurochemical phenotypes of dorsal root ganglion neurons with paclitaxel-induced neurotoxicity in vitro. Nutr Neurosci, 2017, 20 (2): 89-102.

7. Liu D, Liu Z, Liu H, Li H, Pan X, Li Z. Brain-derived neurotrophic factor promotes vesicular glutamate transporter 3 expression and neurite outgrowthof dorsal root ganglion neurons 4

through the activation of the transcription factors Etv4 and Etv5. Brain Res Bull, 2016, 121: 215-226.

8. Yu T, Li L, Chen T, Liu Z, Liu H, Li Z. Erythropoietin attenuates advanced glycation endproducts-induced toxicity of Schwann cells in vitro. Neurochem Res, 2015, 20 (4): 698-712.

9. Yu T, Li L, Bi Y, Liu Z, Liu H, Li Z. Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats. J Pharm Pharmacol, 2014, 66 (8): 1150-1160.

10. Liu D, Bi Y, Liu Z, Liu H, Li Z. The expression of vesicular glutamate transporter 3 and vesicular monoamine transporter 2 induced by brain-derived neurotrophic factor in dorsal root ganglion neurons in vitro. Brain Res Bull, 2014, 100: 93-106.

11. Li Y, Li H, Liu G, Liu Z#. Effects of neuregulin-1β on growth-associated protein 43 expression in dorsal root ganglion neurons with excitotoxicity induced by glutamate in vitro. Neurosci Res, 2013, 76 (1-2): 22-30.

12. Li Y, Liu G, Li H, Xu Y, Zhang H, Liu Z#. Capsaicin-induced activation of ERK1/2 and its involvement in GAP-43 expression and CGRP depletion in organotypically cultured DRG neurons. Cell Mol Neurobiol, 2013, 33 (3): 433-441.

13. Li Y, Liu G, Li H, Wang H, Liu Z#. Different responses of galanin and calcitonin gene-related peptide to capsaicin stimulation on dorsal root ganglion neurons in vitro. Regul Pept, 2013, 184C: 68-74.

14. Xu X, Liu Z, Liu H, Yang X, Li Z. The effects of galanin on neuropathic pain in streptozotocin-induced diabetic rats. Eur J Pharmacol, 2012, 680 (1-3): 28-33.

15. Liu Z, Jiang H, Li H, Liu H, Xu X, Li Z. The effects of neuregulin-1β on neuronal phenotypes of primary cultured dorsal root ganglion neurons by activation of PI3K/Akt. Neurosci Lett, 2012, 511 (1): 52-57.

16. Liu Z, Cai H, Zhang P, Li H, Liu H, Li Z. Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro. Cell Mol Neurobiol, 2012, 32 (2): 191-200.

17. Liu Z, Li H, Zhang W, Li Y, Liu H, Li Z. Neuregulin-1β prevents Ca(2+) overloading and apoptosis through PI3K/Akt activation in cultured dorsal root ganglion neurons with

excitotoxicity induced by glutamate. Cell Mol Neurobiol, 2011, 31 (8): 1195-1201.

18. Xing Y, Chen X, Liu Z, Li H, Liu H, Li Z. Effects of alpha 1- and alpha 2-adrenoreceptor stimulation on galanin mRNA expression in primary cultured superior cervical ganglion neurons. Biomol Ther, 2011, 19 (3): 315-319.

19. Liu Z, Liu Q, Cai H, Xu C, Liu G, Li Z. Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion. Regul Pept, 2011, 171 (1-3): 19-25.

20. Liu Z, Gao W, Wang Y, Zhang W, Liu H, Li Z. Neuregulin-1β regulates outgrowth of neurites and migration of neurofilament 200 neurons from dorsal root ganglial explants in vitro. Peptides, 2011, 32 (6): 1244-1248.

21. Liu H, Wang L, Li H, Liu Z, Wang H, Li Z. Formation of neuromuscular junction-like structure between primary sensory terminals and skeletal muscle cells in vitro. Anat Rec, 2011, 294 (3): 472-478.

22. Feng G, Wang Q, Xu X, Liu Z, Li Z, Liu G. The protective effects of calcitonin gene-related peptide on gastric mucosa injury of gastric ischemia reperfusion in rats. Immunopharm Immunot, 2011, 33(1): 84-89.

23. Liu Z, Liu H, Yang X, Xu X, Zhang W, Li Z. Effects of insulin-like growth factor-1 on expression of sensory neuropeptides in cultured dorsal root ganglion neurons in the absence or presence of glutamate. Int J Neurosci, 2010, 120 (11): 698-702.

24. Cai H, Xu X, Liu Z, Wang Q, Feng G, Li Y, Xu C, Liu G, Li Z. The effects of calcitonin gene-related peptide on bFGF and AQP4 expression after focal cerebral ischemia reperfusion in rats. Pharmazie, 2010, 65 (4):274-278.

25. Yang X, Gong H, Liu Z, Liu H, Wang H, Li Z. Similar and different effects of capsaicin and resiniferatoxin on substance P release and transient receptor potential vanilloid type 1 expression of cultured rat dorsal root ganglion neurons. Methods Find Exp Clin Pharmacol, 2010, 32 (1): 3-11.

26. Gong HC, Yang XD, Liu Z, Xing ZY, Wang HJ, Li ZZ. Regulatory effects of insulin-like growth factor-1 on the expression of sensory neuropeptide mRNAs in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate. Neurosci Bull, 2010, 26 (2): 126-132.

27. Liu H, Liu Z, Xu X, Yang X, Wang H, Li Z. Nerve growth factor regulates galanin and neuropeptide Y expression in primary cultured superior cervical ganglion neurons. Pharmazie, 2010, 65 (3): 219-223.

28. Gong H, Liu Q, Yang X, Liu Z, Liu G, Li Z. Effects of selective alpha 2-adrenoreceptor stimulation on capsaicin-evoked substance P release from primary cultured dorsal root ganglion neurons. Pharmazie, 2010, 65 (3): 202-205.

29. Feng G, Xu X, Wang Q, Liu Z, Li Z, Liu G. The protective effects of calcitonin gene-related peptide on gastric mucosa injury after cerebral ischemia reperfusion in rats. Regul Pept, 2010, 160 (1-3): 121-128.

30. Wang L, Li H, Liu Z, Xu X, Wang H, Li Z. Co-administration of monosialoganglioside and skeletal muscle cells on dorsal root ganglion neuronal phenotypes in vitro. Cell Mol Neurobiol, 2010, 30 (1): 43-49.

31. Liu H, Gong H, Liu Z, Yang X, Liu G, Li Z. Effects of acute exposure of alpha 1- and alpha 2-adrenoreceptor agonist or antagonist on capsaicin-evoked substance P release from dorsal root ganglion neurons in vitro. Pharmazie, 2010, 65 (1): 47-50.

32. Zhang F, Wang L, Liu Z, Xing Z, Wang H, Li Z. Insulin-like growth factor-1 modulates Ca2+ homeostasis and apoptosis of cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate. Pharmazie, 2010, 65 (1): 5-8.

33. Liu Z, Li Z. Nerve growth factor and norepinephrine regulate galanin expression in primary cultured dorsal root ganglion neurons. Pharm Biol, 2009, 47 (7): 634-639.

34. Liu Z, Zhang F, Liu H, Yang X, Wang H, Li Z. Co-administration of nerve growth factor and butyrate regulates vanilloid receptor 1 and substance P levels in cultures of rat dorsal root ganglion neurons. Acta Physiol Hung, 2009, 96 (2): 231-241.

35. Wang L, Liu Z, Liu H, Wan Y, Wang H, Li Z. Neuronal phenotype and tyrosine kinase receptor expression in cocultures of dorsal root ganglion and skeletal muscle cells. Anat Rec, 2009, 292 (1): 107-112.

36. Yang X, Liu Z, Li Z. Effects of norepinephrine on galanin expression in dorsal root ganglion neurons in vitro. Curr Ther Res Clin E, 2009, 70 (1): 19-28.

37. Yang X, Liu Z, Wang L, Liu H, Wang H, Li ZZ. Exogenous galanin regulates capsaicin-evoked substance P release from primary cultured dorsal root ganglion neurons. 7

Neuro Endocrinol Lett, 2008, 29 (6): 911-916.

38. Liu Z, Li Z. Regulation of galanin and galanin receptor 2 expression by capsaicin in primary cultured dorsal root ganglion neurons. In Vitro Cell Dev Biol Anim, 2008, 44 (8-9): 379-384.

39. Liu Z, Liu H, Li Z. Formation of neuromuscular junctions and synthesis of sensory neuropeptides in the co-cultures of dorsal root ganglion and cardiac myocytes. Cell Mol Neurobiol, 2008, 28 (7): 939-947.

40. Liu H, Liu Z, Yang X, Huang F, Ma C, Li Z. Neurotoxicity caused by didanosine on cultured dorsal root ganglion neurons. Cell Biol Toxicol, 2008, 24 (1): 113-121.

41. Liu Huaxiang, Liu Zhen, Yang Xiangdong, Wang Lihong, Li Zhenzhong. Morporlogical alterations induced by didanosine in cultured dorsal root ganglion neurons. Chinese Journal of Neuroanatomy, 2008, 24 (1): 8-12.

42. Liu J, Liu Z, Huang F, Xing Z, Wang H, Li Z. Pioglitazone inhibits hypertrophy induced by high glucose and insulin in cultured neonatal rat cardiomyocytes. Pharmazie, 2007, 62 (12): 925-929.

43. Huang F, Liu Z, Liu H, Wang L, Wang H, Li Z. GM1 and NGF modulate Ca2+ homeostasis and GAP43 mRNA expression in cultured dorsal root ganglion neurons with excitotoxicity induced by glutamate. Nutr Neurosci, 2007, 10 (3/4): 105-111.

44. Yang XD, Liu Z, Liu HX, Ma CH, LI ZZ. Regulatory effect of nerve growth factor on release of substance P in cultured dorsal root ganglion neurons of rat. Neurosci Bull, 2007, 23 (4): 215-220.

45. Liu Huaxiang, Liu Zhen, Avindra Nath, Li Zhenzhong. HIV3B and HIV Ada-M can infect cultured human dorsal root ganglion neurons. Chinese Journal of Neuroanatomy, 2007, 23 (5): 536-541.

46. Xing Y, Liu Z, Wang LH, Huang F, Huaijing Wang HJ, Li ZZ. Butyrate sensitizes the release of substance P and calcitonin gene-related peptide evoked by capsaicin from primary cultured rat dorsal root ganglion neurons. Neuroendocrinol Lett, 2006, 27 (6): 695-701.

47. Liu Huaxiang, Li Zhenzhong, Xing Yi, Huang Fei, Du Fang, Liu Zhen, Chen Shuyan, Wang Lihong, Wang Huaijing. Neurotoxic effect of HIV gp120 on cultured rat dorsal root ganglion neurons. Chinese Journal of Neuroanatomy, 2006, 22 (6): 603-608.

X. ACADEMIC AWARDS

1. 2014, Qilu outstanding young anatomist Award of Shandong Society for Anatomical Sciences

2. 2018, Excellent teaching design cases of “Courses with Ideological and Political Education” of Shandong University, 2nd Award

3. 2018, “Construction and spread of Digital Human Anatomy in China”, the 8th higher education teaching achievement award of Shandong Province Special award (10th investigator)

4. 2018, “Construction and spread of Digital Human Anatomy in China”, National teaching achievement award of Higher Education, 2nd award (14th investigator)

5. 2018, The 11th "young teaching expert" of Shandong University

6. 2019, Excellent teaching design cases of “Courses with Ideological and Political Education” of Shandong University, 1st Award