1.Research interest

We focus on the identification of metastasis suppressors and functional characterization of their involvement in tumor microenvironment during tumor progression.

We are also interested in the regulators (ncRNAs) of cancer stem cell expansion and differentiation that have significant impact on tumor progression and metastasis.

2. Biography

Jing Hao is a Professor of Histology and Embryology at Shandong University. She graduated with a bachelor's degree from Shandong Medical University in 1994，and completed her graduate study at Shandong University in 2000. Dr. Hao joined the faculty of Shandong University as an Instructor of Histology and Embryology in 2000. She was promoted to Associate Professor in 2001 and to Professor in 2007.

Dr. Hao's research focuses on the molecular mechanisms of breast cancer metastasis. She has published over 20 original articles in journals including PNAS, Stem Cells, and Carcinogenesis. Her work discovered new tumor suppressor genes that inhibit metastasis and chemoresistance of breast cancer, delineated the manipulation of tumor microenvironment to control cancer metastasis.

3. Education

1989-1994 B.S.(Clinical Medicine) Shandong Medical University

1994-1997 M.S.(Histology&Embryology) Shandong Medical University

1997-2000 Ph.D.(Histology&Embryology) Shandong University

2002-2006 Postdoctoral UT Southwestern Medical Center, TX, USA

4. Honors & Awards

2010 Fund for distinguished youth scholars in Shandong University

5. Publication

1）Zhang X, Liu R, Zhao N, Ji S, Hao C, Cui W, Zhang R,Hao J.Sohlh2inhibits breast cancer cell proliferation by suppressing Wnt/β-catenin signaling pathway. Mol Carcinog. 2019;58(6):1008-1018.

2）Zhang X, Liu X, Cui W, Zhang R, Liu Y, Li Y,Hao J. Sohlh2 alleviates malignancy of EOC cells under hypoxia via inhibiting the HIF1α/CA9 signaling pathway. 2019;

3）Liu X, Gao Q, Zhao N, Zhang X, Cui W, Sun J, Fu J,Hao J. Sohlh1 suppresses glioblastoma cell proliferation, migration, and invasion by inhibition of Wnt/β-catenin signaling. Mol Carcinog. 2018 ;57(4):494-502.

4）Ji S, Zhang W, Zhang X, Hao C, Hao A, Gao Q, Zhang H, Sun J,Hao J.Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8.Oncotarget. 2016 ;7(31):49411-49424.

5)Zhang H, Hao C, Wang Y, Ji S, Zhang X, Zhang W, Zhao Q, Sun J, Hao J. Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9.Mol Carcinog. 2016 Jul;55(7):1127-37

6)Zhang X, Liu R, Su Z, Zhang Y, Zhang W, Liu X, Wang F, Guo Y, Li C,Hao J.Immunohistochemical Study of Expression of Sohlh1 and Sohlh2 in Normal Adult Human Tissues.PLoS One. 2015 Sep 16;10(9):e0137431.

7)Zhang X, Zhang H, Gao Q, Ji S, Bing L,Hao J. Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway.Reprod Biomed Online. 2015; 30(5):514-21.

8)Zhang H, Zhang X, Ji S, Hao C, Mu Y, Sun J,Hao J.Sohlh2 inhibits ovarian cancer cell proliferation by upregulation of p21 and downregulation of cyclin D1.Carcinogenesis. 2014; 35(8):1863-71.

9)Zhang X, Shi K, Li Y, Zhang H,Hao J. Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells.Reprod Toxicol. 2014; 45: 87-93.

10)Li Y, Zhang Y, Zhang X, Sun J,Hao J.BMP4/Smad signaling pathway induces the differentiation of mouse spermatogonial stem cells via upregulation of Sohlh2.Anat Rec (Hoboken). 2014 ; 297(4):749-57.

11) Ding X, Zhang X, Mu Y, Li Y,Hao J. Effects of BMP4/SMAD signaling pathway on mouse primordial follicle growth and survival via up-regulation of Sohlh2 and c-kit. Mol Reprod Dev. 2013; 80(1):70-8.

12) Li Y, Gao Q, Yin G, Ding X,Hao J.WNT/β-Catenin-Signaling Pathway Stimulates the Proliferation of Cultured Adult Human Sertoli Cells via Upregulation of C-myc Expression.Reprod Sci. 2012; 19(11):1232-40.

13) Zhang S, Li Y, Wu Y, Shi K, Bing L,Hao J. Wnt/β-Catenin Signaling Pathway Upregulates c-Myc Expression to Promote Cell Proliferation of P19 Teratocarcinoma Cells. Anat Rec (Hoboken). 2012; 295(12): 2104-13.

14)Hao, J, Yamamoto, M,Richardson,TE,Chapman KM,Denard BS,Hammer RE,Zhao, GQ, AND Hamra FK.. Sohlh2 knockout mice are male-sterile because of degeneration of differentiating type A spermatogonia. Stem Cells. 2008; 26(6):1587-97.

15) Hao, J, Li, TG, Qi, X, Zhao DF, and Zhao, GQ. WNT/catenin pathway upregulatesStat3and converges on LIF to prevent differentiation of embryonic stem cells. Dev Biol.2006; 290, 81-91.

16) Qi, X, Li, TG,Hao, J, Hu, J, Wang, J, Simmons, H, Mishina, Y, and Zhao, GQ. BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase (MAPK) pathways. Proc. Natl. Acad. Sci. USA 2004; 101, 6027-6032. (co-first-author)

6. Teaching

Semester Course titles

Spring 2001-present Histology & Embryology

Spring 2017-present Introduction of Morphology

Fall 2008-present Progression of Stem Cell Research

Fall 2017-present Cell Signaling and Disease

7. Contact:

Office time: Monday to Friday

Office address: Department of Anatomy and Histology & Embryology

Basic Medicine of Shandong University

Building 6-220

44 Wenhuaxi Road

Jinan Shandong 250012

Phone: 0531-88382050

Email address:haojing@sdu.edu.cn