Aijun Hao
Professor (M.D. /Ph.D.)
School of Basic Medical Sciences, Shandong University
44 Wenhua Xi Road, Jinan, Shandong 250012, P.R.China
aijunhao@sdu.edu.cn
Room:6232, Building 6
Phone:+8613854102903；86-0531-88382050
Dr Hao graduated from Shandong Medical University with a M.D. in Clinical Medicine. She completed a PhD at the National University of Singapore. She returned to Shandong University as academic staff in 2004, following research position in molecular biology at Institute of Molecular and Cellular Biology of Singapore. She is head of the Department of Histology and Embryology of Shandong University; Vice Chairman of Shandong Society for Anatomical Sciences; Member of The American Society for Neuroscience; Member of The American Society for Cell Biology.
The main research interest is neural development and related diseases. Her research work is focused on neural stem cell and the underlying mechanisms of proliferation and differentiation. This topic has applications to neural injury and neurodegeneration diseases
Publications
1. Li, Xian, Chen, Xueran, Zhou, Wenjuan, Ji, Shufang, Li,Xinyue, Li,Guanchong, Liu, Guowei, Wang, Fuwu, Hao, Aijun(*), Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14. Neuroscience. 2017 Aug 4. pii: S0306-4522(17)30550-X.
2. Chen, Xueran, Du, Zhaoxia, Li, Xian, Wang, Liyan, Wang, Fuwu, Shi, Wei, Hao, Aijun(*), Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity. Molecular Neurobiology. 2016.10.01，53（8）：5722~5736
3. Shi Wei，Chen Xueran，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Hao Aijun(*), ZDHHC16 Modulates FGF/ERK Dependent Proliferation of Neural Stem/Progenitor Cells in the Zebrafish Telencephalo, Developmental Neurobiology，2016.9.3，76（9）：1014~1028
4. Du, Zhaoxia, Chen, Xueran(*), Li, Xian, He, Kun, Ji, Shufang, Shi,Wei, Hao, Aijun(*)，Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Biochemical and Biophysical Research Communications，2016.6.24，475：194~201
5. Guo Yuji, Liu Shangming, Zhang Xianghong, Wang Liyan, Gao Jiangang, Han Aiqing(*), Hao Aijun (*), G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice. Laboratory Investigation，2015.12.1，95：1439~1449
6. Wang Fen，Chen Xueran，Shi Wei，Yao Linli，Gao Ming，Yang Yang，Hao Aijun(*)，Zdhhc15b Regulates Differentiation of Diencephalic Dopaminergic Neurons in Zebrafish. Journal of Cellular Biochemistry，2015.12.01，116：2980~2991
7. Liu, Shangming，Guo, Yuji，Yuan, Qiuhuan，Pan, Yan，Wang, Liyan，Liu, Qian，Wang, Fuwu，Wang, Jingjing(*) , Hao, Aijun(*)，Melatonin prevents neural tube defects in the offspring of diabetic pregnancy. Journal of Pineal Research，2015.11.01，59：508~517
8. Shi Wei，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Chen Xueran(*)，Hao Aijun(*)，ZDHHC17 promotes axon outgrowth by regulating TrkA–tubulin complex formation，Molecular and Cellular Neuroscience，2015.9.01，68：194~202
9. Chen Wang，Xueran Chen，Wei Shi，Fen Wang，Zhaoxia Du，Xian Li，Yao Yao，Tong Liu，Tong Shao，Gang Li，Hao Aijun(*)，2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Neurotoxicology and Teratology，2015.7.01，50：53~63
10. Wang, Fuwu，Zhou, Huaiyu，Du, Zhaoxia，Chen, Xueran，Zhu, Faliang，Wang, Zhen，Zhang, Yanmin，Lin, Lin，Qian, Mingyu，Zhang, Xianghong，Li, Xingang(*), Hao, Aijun(*)，Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. European Journal of Pharmacology，2015.2.5，748：157~165
11. Zhang yanmin，Ni Shilei，Huang Bin，Wang Liyan，Zhang Xianghong，Li Xian，Wang Han，Liu Shuai，Hao Aijun(*), Li Xingang(*)，Overexpression of SCLIP promotes growth and motility in glioblastoma cells. Cancer Biol Ther.，2015.1.1，16：97~105
12. Chen X, Shi W, Wang F, Du Z, Yang Y, Gao M, Yao Y, He K, Wang C, Hao A*. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Stem Cells Dev, 2014, 23(16):1899-1909.
13.Chen X, Du Z, Shi W, Wang C1, Yang Y, Wang F, Yao Y, He K, Hao A*. 2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation. Stem Cell Res, 2014, 12(2):481–491.
14. Chen X, Li X, Du Z, Shi W, Yao Y, Wang C, He K, Hao A*. Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation. Journal of Pineal Research, 2014, 57(2):168–176
15. Liu, D., Wang, Z., Zhan, J., Zhang, Q., Wang, J., Xian, X., Luan, Q., and Hao, A*. Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis. Pharmacol Biochem Behav ,2014,116, 55-63.
16. Wang, Z., Liu, D., Zhang, Q., Wang, J., Zhan, J., Xian, X., Du, Z., Wang, X., and Hao, A*.Palmitic acid affects proliferation and differentiation of neural stem cells in vitro. J Neurosci Res, 2014.
17. Zhang Y, Liu Q, Wang F, Ling EA, Liu S, Wang L, Yang Y, Yao L, Chen X, Wang F, Shi W, Gao M, Hao A*. Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α. J Pineal Res. 2013 Sep;55 (2):121-30. doi: 10.1111/jpi.12052. Epub 2013 Mar 29.
18. Li, L., Wang, J., Chau, J.F., Liu, H., Li, B., Hao, A., and Li, J*. Smad1 stabilization and delocalization in response to the blockade of BMP activity. Cell Mol Biol Lett,2013 ,18, 340-354.
19. Liu, Q., Wang, L., Wang, Z., Yang, Y., Tian, J., Liu, G., Guan, D., Cao, X., Zhang, Y*., and Hao, A. GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1alpha destabilization. Carcinogenesis, 2013, 34, 1728-1736.
20. Wang, L., Liu, Q., Zhao, H., Cui, K*., Yao, L., Nie, F., Jin, G., Hao, A*., and Wong, S.T.. Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion. J Neurosci Res ,2013a, 91, 128-137.
21. Wang, Z., Liu, D., Zhan, J., Xie, K., Wang, X., Xian, X., Gu, J., Chen, W., and Hao, A*. Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice. Pharmacol Res ,2013b, 76, 84-97.
22. Yao, L., Cao, Q., Wu, C., Kaur, C., Hao, A., and Ling, E.A*. Notch signaling in the central nervous system with special reference to its expression in microglia. CNS Neurol Disord Drug Targets ,2013a ,12, 807-814.
23. Yao, L., Kan, E.M., Kaur, C., Dheen, S.T., Hao, A., Lu, J., and Ling, E.A*. Notch-1 Signaling Regulates Microglia Activation via NF-kappaB Pathway after Hypoxic Exposure In Vivo and In Vitro. PLoS One, 2013b, 8, e78439.
24. Yao, L., Kan, E.M., Lu, J., Hao, A., Dheen, S.T., Kaur, C*., and Ling, E.A*. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation, 2013c, 10, 23.
25. Yuan, Q., Zhao, S., Liu, S., Zhang, Y., Fu, J., Wang, F., Liu, Q., Ling, E.A., and Hao, A*. Folic acid supplementation changes the fate of neural progenitors in mouse embryos of hyperglycemic and diabetic pregnancy. J Nutr Biochem, 2013a, 24, 1202-1212.
26. Yuan, Q., Zhao, S., Wang, F., Zhang, H., Chen, Z.J., Wang, J., Wang, Z., Du, Z., Ling, E.A., Liu, Q*., Hao, A*. Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase. Stem Cell Res ,2013b, 10, 257-266.
27. Chen, Y., Lu, H., Liu, Q., Huang, G., Lim, C.P., Zhang, L., Hao, A*., and Cao, X*. Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity. J Biol Chem ,2012, 287, 27227-27235.
28. Ma, G., Li, L., Hu, Y., Chau, J.F., Au, B.J., Jia, D., Liu, H., Yeh, J., He, L., Hao, A*., and Li, B*. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol ,2012, 4, 118-120.
29. Wang, J., Hao, H., Yao, L., Zhang, X., Zhao, S., Ling, E.A., Hao, A*, and Li, G*. Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells. J Pineal Res, 2012a, 53, 180-187.
30. Wang, J., Yao, L., Zhao, S., Zhang, X., Yin, J., Zhang, Y., Chen, X., Gao, M., Ling, E.A., Hao, A*, Li, G*. Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells. Cancer Biol Ther, 2012b, 13, 389-400.
31. Wang, L., Zhao, H., Cui, K*., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., Jin, G., Liu, Q*., Wong , ST. Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening. Biosci Trends, 2012c, 6, 192-200.
32. Wang, Z., Liu, D., Wang, F., Liu, S., Zhao, S., Ling, E.A., and Hao, A*. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling. Br J Nutr, 2012d, 107, 229-241.
33. Wang, Z., Liu, D., Wang, J., Liu, S., Gao, M., Ling, E.A., and Hao, A*. Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro. J Pineal Res, 2012e, 52, 253-264.
34. Liu, D., Wang, Z., Liu, S., Wang, F., Zhao, S., and Hao, A* Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells. Neuropharmacology, 2011a, 61, 592-599.
35. Liu, S., Yuan, Q., Zhao, S., Wang, J., Guo, Y., Wang, F., Zhang, Y., Liu, Q., Zhang, S., Ling, E.A., Hao, A*. High glucose induces apoptosis in embryonic neural progenitor cells by a pathway involving protein PKCdelta. Cell Signal, 2011b, 23, 1366-1374.
36. Ren, S., Wang, X., Ma, B*., Yuan, Q., Zhang, H., Yu, X., and Hao, A. Arnebia preventing the expression of Muc1 protein decrease results in anti-implantation in early pregnant mice. Contraception, 2011, 83, 378-384.
37. Shidou Zhao（#）, Qiuhuan Yuan（#）, Hongbo Hao, Yuji Guo, Shangming Liu, Yanmin Zhang, Jianli Wang, Huijuan Liu, Fuwu Wang, Kai Liu, Eng-Ang Ling, and Aijun Hao（*）, Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma,J Pathol, 2011, 223: 672-682。
38. Yuji Guo（#）, Shangming Liu（#）, Ping Wang, Shidou Zhao, Fuwu Wang, Lujun Bing, Yanmin Zhang, Eng-Ang Ling, Jiangang Gao（*）and Aijun Hao（*）, Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas, Histopathology, 2011, 59: 763-775。
39. Yanmin Zhang（#）, Hongbo Hao（#）, Shidou Zhao, Qian Liu, Qiuhuan Yuan, Shilei Ni, Fuwu Wang, Shangming Liu, Liyan Wang, and Aijun Hao（*）, Downregulation of GRIM-19 promotes growth and migration of human glioma cells, Cancer Sci, 2011, 102: 1991-1999。
40. Fu-wu Wang（#）, Hong-bo Hao, Shi-dou Zhao, Yan-min Zhang, Qian Liu, Hui-juan Liu, Shang-ming Liu, Qiu-huan Yuan, Lu-jun Bing, Eng-Ang Ling, Ai-jun Hao, Roles of activated astrocyte in neural stem cell proliferation and differentiation, Stem Cell Res. 2011 Jul;7(1):41-53.
41. Jie Fu（#）, Shi-Dou Zhao, Hui-Juan Liu, Qiu-Huan Yuan, Shang-Ming Liu, Yan-Min Zhang, Eng-Ang Ling, Ai-Jun Hao, Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. J Pineal Res. 2011 Aug;51(1):104-12.
Teaching andCourse:
Histology and Embryology
Clinical Embryology
Progress in stem cell
Cell signalingand disease
