Dr. Zhen Wang
Department of Physiology,
Schoolof Basic Medical Sciences,ShandongUniversity
44#, Wenhua Xi Road, Jinan, Shandong, 250012, P.R. China.
Room:6308
Telephone: 86-531-88383902
E-mail:wangzhen@sdu.edu.cn
Research interest
1. Focus on the pathogenesis and intervention strategy of central nervous system related diseases, such ashypoxia-ischemic brain damage, subarachnoid hemorrhage,spinal cord injury,cerebral ischemia.
2. Focuses on the inflammatory reaction of central nervous system injury, and provides new strategies and targets for the treatment of central nervous system injury.
Education and research experience
2014 - present Associate professor, Department of Physiology, School of Basic Medical Sciences, Shandong University,China
2011-2014 Postdoctoral fellow,Department of Neurosurgery, Qilu Hospital Affiliated to Shandong University
2008-2009 Visiting scholar, Department of Internal Medicine, Cardiovascular Research Center, Graduate Center for Nutritional Sciences, University of Kentucky, USA
2006-2011 PH.D.,Physiology, Shandong University School of Medicine, Shandong University
2000-2003 M.S.,Physiology, Shandong University School of Medicine, Shandong University
Funding
1.Exosomesderived fromhydrogen sulfide-preconditionedBMSCsprotect neonatal mice against hypoxia-ischemic brain damage viamiR-9/TN-C,2019.01-2022.12, the National Natural Science Foundation of China
2. Modulation of Shh pathway contributes to the role of H2S in hippocampus neurogenesis in neonatal mouse following hypoxia-ischemia brain damage by conditional gene knock-out technique, 2017.01-2020.12,the National Natural Science Foundation of China
Teaching course
1. Physiology
2.Physiological experiment
3.Medical function experiment
4. The basis and clinic of nervous system diseases
Publications(* indicates corresponding author,#indicates first author)
1. Chu X#, Cao L, Yu Z, Xin D, Li T, Ma W, Zhou X, Chen W, Liu D, Wang Z*. Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation. J Neuroinflammation. 2019; 16: 104. Published online 2019 May 18. doi: 10.1186/s12974-019-1488-2
2. Zhou X#, Chu X#, Xin D, Li T, Bai X, Qiu J, Yuan H, Liu D, Wang D , Wang Z*. L-Cysteine-Derived H2S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice. Frontier in Molecular Neuroscience. 2019 March 11;12:58.
3. Yang C#, Tong Li#, Xue H, Wang L, Deng L, Xie Y, Bai X, Xin D, Yuan H, Qiu J, Wang Z*, Gang Li*. Inhibition of Necroptosis Rescues SAH-Induced Synaptic Impairments in Hippocampus via CREB-BDNF Pathway. Frontier in Neuroscience. 2019 January 7; 12:990.
4. Li J#, Xue H, Li T, Chu X, Xin D, Xiong Y, Qiu W, Gao X, Qian M, Xu J, Wang Z*, Li G*. Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE-/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage. Biochemical and Biophysical Research Communications. 2019 March 19, Pages 565-572.
5.Xie YK#, Zhou X#, Yuan HT, Qiu J, Xin DQ, Chu XL,WangDC*, Wang Z*
.Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting
oxidative stress and endoplasmic reticulum stress. Neural Regen Res. 2019
Oct;14(10):1734-1742.
6.Xin D#, Chu X, Bai X, Ma W, Yuan H, Qiu J, Liu C, Li T, Zhou X, Chen W, Liu D, Wang Z*. l-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation. Brain Behav Immun. 2018 Oct; 73: 222-234. PubMed
7. Liu S#, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D, Wang Z*. Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: role of oxidative stress and endoplasmic reticulum stress. Redox Biology 2017 Jul 14; 13:528-540. PubMed
8. Li T#, Wang L#, Hu Q, Liu S, Bai X, Xie Y, Zhang T, Bo S, Gao X, Wu S, Li G*, Wang Z*. Neuroprotective Roles of l-Cysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H2S Pathway Following Subarachnoid Hemorrhage in Rats. Frontiers in Neurology. 2017 May 2; 8:176. doi: 10.3389/fneur.2017.00176. eCollection 2017.
9. Ge L#, Wei LH, Du CQ, Song GH, Xue YZ, Shi HS, Yang M, Yin XX, Li RT, Wang XE, Wang Z*. Song WG*. Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats. Oncotarget. 2017 Jun 27; 8(26):42314-42331
10. Hu Q#, Li T#, Wang L, Xie Y, Liu S, Bai X, Zhang T, Bo S, Xin D, Xue H, Li G*, Wang Z*. Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Frontiers in Cellular Neuroscience. 2017 Jan 18; 10:306
11. Li T#, Liu H, Xue H, Zhang J, Han X, Yan S, Bo S, Liu S, Yuan L, Deng L, Li G*, Wang Z*. Neuroprotective effects of hydrogen sulfide against early brain injury and secondary cognitive deficits following subarachnoid hemorrhage. Brain Pathology. 2017 Jan;27(1):51-63.
12. Zhang Q#, Liu S, Li T, Yuan L, Liu H, Wang X, Wang F, Wang S, Hao A, Liu D*, Wang Z*. Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential. Oncotarget. 2016 Sep 6;7(36):58089-58104.
13. Bai X#, Liu S, Yuan L, Xie Y, Li T, Wang L, Wang X, Zhang T, Qin S, Song G, Ge L*, Wang Z*. Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Research. 2016 Sep 1;1646:410-7.
14. Yuan L#, Liu S, Bai X, Gao Y, Liu G, Wang X, Liu D, Li T, Hao A, Wang Z*. Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice. Journal of Neuroinflammation. 2016 Apr 13;13(1):77.
15. Zhang Q#, Yuan L#, Zhang Q, Gao Y, Liu G, Xiu M, Wei X, Wang Z*, Liu D*. Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. International Immunopharmacology. 2015 Jul 27;28(1):578-587. PubMed
16. Zhang Q#, Yuan L, Liu D, Wang J, Wang S, Zhang Q, Gong Y, Liu H, Hao A, Wang Z*. Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. Pharmacological Research. 2014 Jun; 84:32-44.
17. Liu D#, Xie K, Yang X, Gu J, Ge L, Wang X, Wang Z*. Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behavioural Brain Research. 2014 May 1; 264:9-16.
18. Liu D#, Zhang Q, Gu J, Wang X, Xie K, Xian X, Wang J, Jiang H, Wang Z*（. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:21-9.
