Shuyan Yu, PhD
Professor, Department of Physiology and Pathophysiology, School of Basic Medical Sciences,Shandong University
Tel：0531-88382571
E-mail：shuyanyu@sdu.edu.cn
Wenhuaxilu Road 44#, Jinan, Shandong, 250012, China
Medical education:
2005-2008 Shandong University, China, PhD
2006-2007 University of British Columbia, Canada, Visiting Scholar
1999-2002 Shandong University, China, Master Degree
Research Interests:
1. Neural mechanisms of post-traumatic stress disorder (PTSD) and depression
2. Neuronal plasticity in depression
3. Cellular and molecular mechanisms of antidepressants
Projects:
1. Microglial IL-1β modulates synaptic plasticity via SSH1/Cofilin pathway in depression. (2018.1-2022.12) The National Natural Science Foundation of China (NSFC81873796)
2. miR-134 mediated synaptic plasticity in depression. (2015.1-2018.12) The National Natural Science Foundation of China (NSFC81471371)
3. Glutamate receptor mediated synaptic plasticity in depression. (2012.1-2014.12) The National Natural Science Foundation of China (NSFC81101006)
4. Role of IL-1β mediated neuroplasticity in depression. (2018.1-2020.12) The Key Research and Development Foundation of Shandong Province (2018GSF118050)
Publications:
1. Song Q, Feng YB, Wang L, Shen J, Li Y, Fan C, Wang P,Yu SY*. COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats.Neuropharmacology. 2019, Dec 1, 160: 107779.
2. Wang P, Feng YB, Wang L, Li Y, Fan C, Song Q,Yu SY*. Interleukin-6: Its role and mechanisms in rescuing depression-like behaviors in rat models of depression.Brain Behav Immun. 2019 Nov; 82:106-121.
3. Fan C, Song Q, Wang P, Li Y, Yang M,Yu SY*. Neuroprotective effects of curcumin on IL-1β-induced neuronal apoptosis and depression-like behaviors caused by chronic stress in rats.Frontiers in Cellular Neuroscience. 2019 Jan 07, 12:516.
4. Fan C, Song Q, Wang P, Li Y, Yang M,Yu SY*. Neuroprotective effects of ginsenoside-Rg1 against depression-like behaviors via suppressing glial activation, synaptic deficits, and neuronal apoptosis in rats.Frontiers in Immunology. 2018 Dec 07, 9:2889.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292928/
5. Song Q, Fan C, Wang P, Li Y, Yang M,Yu SY*. Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression.Journal of Neuroinflammation. 2018 Dec 08; 15:338
6. Fan C, Song Q, Wang P, Li Y, Yang M, Liu B,Yu SY*.Curcumin Protects Against Chronic Stress-induced Dysregulation of Neuroplasticity and Depression-like Behaviors via Suppressing IL-1β Pathway in Rats.Neuroscience.2018, 392: 92-106.
7. Fan C, Zhu X, Song Q, Wang P, Liu Z,Yu SY*.MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1/cofilin signaling in rats.Neuropharmacology.2018, 131: 364–376.
8. Zhu X, Gao R, Liu Z, Cheng Z, Qi Y, Fan C,Yu SY *. Ginsenoside Rg1 reverses stress-induced depression-like behaviors and BDNF expression within the prefrontal cortex.European Journal of Neuroscience. Volume44, July 2016, 1878-1885.
9. Liu Z, Qi Y, Cheng Z, Zhu X, Fan C,Yu SY *. The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats.Neuroscience.Volume 322, 13 May 2016, 358–369.
10. Zhang L, Luo JX, Zhang M, Yao W, Ma X,Yu SY *. Effects of curcumin on chronic unpredictable mild stress-induced depressive-like behavior and structural plasticity in the lateral amygdala of rats.The International Journal of Neuropsychopharmacology.2014 May; 17（05）:793-806
11. Luo JX, Zhang L, Ning NN, Jiang H,Yu SY *. Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat.Behavioural Brain Research.2013, 253:48-53.
12. Lin Zhang, Tianyuan Xu, Shuang Wang, Lanqing Yu, Dexiang Liu, Renzhi Zhan,Yu SY *. NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test.Prog Neuropsychopharmacol Biol Psychiatry. 2013, 40: 12–17.
13.Yu SY, Zhang M, Luo J, Zhang L, Shao Y, Li G*.Curcumin ameliorates memory deficits vianeuronal nitric oxide synthase in aged mice.Prog Neuropsychopharmacol Biol Psychiatry.2013, 45:47-53.
14.Yu SY *, Gao R, Zhang L，Luo J, Jiang H, Wang S.Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice.Prog Neuropsychopharmacol Biol Psychiatry.2013, 44:210-6.
15.Lin Zhang, Tianyuan Xu, Shuang Wang, Lanqing Yu, Dexiang Liu, Renzhi Zhan,Yu SY *. Curcumin produces antidepressant effects via activating MAPK/ERK- dependent brain-derived neurotrophic factor expression in the amygdala of mice.Behavioural Brain Research.2012, 235(1):67-72.
16. Lin Zhang, Hui Wang, Qin Li, Renzhi Zhan,Yu SY *. Purinergic modulation of hypoxic regulation via the rostral ventral lateral medulla in rats.Respiratory Physiology＆Neurobiology.2012, 184(1): 48-54.
17.Yu SY *, Wang G, Wang H, Zhang H, Li Q. Raphe pallidus modulate Bötzinger complex induced inhibition of the phrenic nerve activity in rats.European Journal of Neuroscience. 2011, 34(7):1113-20.
18.Yu SY *, Wu DC, Zhan RZ. GluN2B subunits of the NMDA receptor contribute to the AMPA receptor internalization during long-term depression in the lateral amygdala of juvenile rats.Neuroscience. 2010, 171(4):1102-8.
19.Yu SY, Wu DC, Liu L, Ge Y, Wang YT*. Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala.Journal of Neurochemistry.2008, 106(2):889-99.
