Xiao Yu
Ph.D, Professor, Young Qilu Scholar;
Vice Chair of the Department of Physiology and Pathophysiology
Assistant Dean ofShandong University School ofBasicMedical Sciences
44 Wenhua Xi Road,Building 6, 6326; Jinan 250012; China
Phone (office):086-531-88381910
Phone (cell):15969701459
Email:yuxiao@sdu.edu.cnoryuxiaosdu@126.com
Education
1999 B.Sc. University of Science and Technology of China (USTC)
2004 PhD. Chinese Academy of Sciences (CAS)
Postdoctoral Training
2004/09-2005/09Postdoctoral Associate, Centers for Molecular Medicine, State University of New York, Stony Brook, NY, USA
2005/09-2009/11 Postdoctoral Fellow, Indiana University School of Medicine, Indianapolis, IN, USA
Appointments
2009/11-2016/07Professor, Young Qilu Scholar
Department ofPhysiology, Shandong University School of Medicine
2016/07- Professor, Young Qilu Scholar
Department ofPhysiologyandPathophysiology, Shandong University School ofBasicMedical Sciences
Academy Memberships
Member of Chinese Association for Physiological Sciences(CAPS) Council
Member of Biophysical Society of China, Neurobiophysics and Neuroinformatics committee
Honors and Awards
2018 NSFC Excellent Young Scientist, China
2013Shandong Province Outstanding Fund, Shandong
2009New Century Excellent Talents in University, China
2008 Bowman Award, Indiana University School of Medicine, USA
2002 SfN/IBRO Travel Fellowship
Research Interests
Professor Yu focuses on the regulatory mechanism of the endocrine system, especially the homeostasis of the pancreatic beta cells and islet circuit. During the last decade, Professor Yu has found the critical role of the the δ-β islet circuit and epigenetics of the δ cells in maintaining the islet homeostasis, elucidated the precise mechanism in regulation of the pancreatic β cell homeostasis by transmembrane signaling and has developed specific approaches to regulate the islet homeostasis by targeting to the phosphorylation network downstream of transmembrane signaling. Professor Yu has published over twenty papers with first or correspondence author in high impact journals, including J Clin Invest, PNAS, Cell Research, eLife, Cell Reports, Diabetologia, J Physiol. and J Biol. Chem. Professor Yu is supported by the NSFC through the Excellent Young Scientist programme.
SELECTED PUBLICATIONS(#, correspondence author)
1. Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#,Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreaticdcell paracrine interactions. J Clin Invest. 2017;127(7):2631-2646.
2. Li N, Yang Z, Li Q, Yu Z, Chen X, Li JC, Li B, Ning SL, Cui M, Sun JP,Yu X#.Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death Dis. 2018 Jun 7; 9(6):682. doi:10.1038/s41419-018-0741-4.
3. Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP#,Yu X#. (2018) Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J. 2018; 32(1): 73-82.
4.Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#,Yu X#, Sun JP#. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. eLife. 2018 Feb 2; 7. pii: e33432.
5. Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Ma R,Yu X#, Sun JP#. (2014) The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research2014 Sep;24(9):1067-90.
6. Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#,Yu X#. (2016) Crystal structure and substrate specificity of PTPN12. Cell Reports 2016; 15(6):1345-58. IF 8.4.
7. Wang HM, Dong JH, Li Q, Hu Q, Ning SL, Zheng W, Cui M, Chen TS, Xie X, Sun JP#,Yu X#. (2014) A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1. Diabetologia. 2014 Sep;57(9):1899-910.
8. Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, Kang X, Zheng L, Zhang J, Raoux M, Lang J, Li Q, Su J,Yu X#, Chen L#, Zhou Z#. (2015) Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 2015 Feb;58(2):324-33.
9. Ning SL, Zheng WS, Su J, Liang N, Li H, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX,Yu X#, Sun JP#.Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells. Br J Pharmacol. 2015172(21):5050-67.
10.Yu X*, Sun JP*, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY. (2007) Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc. Natl. Acad. Sci. USA. 2007 Dec, 104, 19767-19772.
