Lifen Gao, Ph.D.
1.RESEARCH INTERESTS
My research interests are focused on macrophages and immune regulation involved in tumor and metabolism-related diseases. Particularly, there are three articulations on which I focus my studies:
(1) Regulation of Tim-4 on macrophages
(2) Tumor immunotherapy including CAR-T and immune escape
(3) Obesity, type 2 diabetes, and NAFLD
2.PERSONAL DATA
Name: Lifen Gao Sex: Female
Title: Professor Degree: Ph. D
Major: Immunology Date of Birth: April,1972 Nationality: Chinese Health: Excellent
3.EDUCATIONAL BACKGROUND
2008-2009: Postdoctoral research fellow in Microbiology and Immunology, University of Texas Health Science Center at San Antonio
2001-2003: Postdoctoral Fellow in Immunology, Institute of Immunology, Shandong University of School Medicine
1996—2001: Studying inWuhanUniversity,Hubbei Province; Majoring in Immunology (Master&PhD in Medicine)
1991—1996: Studying inBinzhou Medical College,ShandongProvince; Majoring in Clinical Medicine (BA in Clinical Medicine)
4.HONORS AND AWARDS
AWARDS
2018 Ma CH, Liang XH,Gao LF, et al. The mechanism of hepatitis b virus and immune microenvironment in chronic inflammation and malignant transformation. First prize of natural science award of Ministry of Education
PATENTS
2008 Sun WS,Gao LF, Liu YG, Liang XH.Human sDR5 as drugs acting on viral hepatitis B. State Intellectual Property Office of the People’s Republic ofChina. No. ZL200610044672.8 Transferred to Shenzhen zhong ke ai shen pharmaceutical co. LTD
5.PUBLICATIONS AND BOOKS
SELECTED RESEARCH PAPERS(*Corresponding author)
1.Liu W, Bai F, Wang H, Liang Y, Du X, Liu C, Cai D, Peng J, Zhong G, Liang X, Ma C,Gao L*.Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages.J Immunol. 2019;203(4):990-1000.
2.Zhao D, Guo M, Liu B, Lin Q, Xie T, Zhang Q, Jia X, Shu Q, Liang X,Gao L*, Ma C*.Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE. J Leukoc Biol. 2017;102(6):1313-1322.
3.Xu L, Zhao P, Xu Y, Gao L, Wang H, Jia X, Ma H, Liang X, Ma C,Gao L*.Tim-4 protects mice against lipopolysaccharide-induced endotoxic shock by suppressing the NF-κB signaling pathway. Lab Invest. 2016; 96(11):1189-1197.
4.Zhao P, Wang H, Li T, Lei C, Xu X, Wang W, Liang X, Ma C,Gao L*. Increased TIM-4 negatively correlates with IL-1β levels in type 2 diabetes. J Diabetes. 2016,8(2):199-205.
5.Wan F,Gao L, Lu Y, Ma H, Wang H, Liang X, Wang Y, Ma C. Proliferation and osteo/odontogenic differentiation of stem cells from apical papilla regulated by Zinc fingers and homeoboxes 2: An in vitro study. Biochem Biophys Res Commun. 2016 Jan 15;469(3):599-605.(co-first author)
6.Zhang Q, Wang H, Wu X, Liu B, Liu W, Wang R, Liang X, Ma C,Gao L*. TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner. Br J Cancer. 2015;113(10):1484-1492.
7.Xu LY, Qi JN, Liu X, Ma HX, Yuan W, Zhao PQ, Liang XH, Xu Y, Wang HX, Xu XY, Wang W, Ma CH,Gao LF*.Tim-4 Inhibits NO Generation by Murine Macrophages. PLoS One. 2015;10(4):e0124771.
8.Xu L, Qi J, Zhao P, Liang X, Ju Y, Liu P, Liu B, Guo C, Zhang L, Ma C,Gao L*. T cell immunoglobulin- and mucin-domain-containing molecule-4 attenuates concanavalin A-induced hepatitis by regulating macrophage. J Leukoc Biol. 2010;88(2):329-336.
9.Zhao P, Xu L, Wang P, Liang X, Qi J, Liu P, Guo C, Zhang L, Chunhongma,Gao L*. Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus.Cell Mol Immunol.2010;7(2):152-156.
10.Yan X, Xu L, Qi J, Liang X, Ma C, Guo C, Zhang L, Sun W, Zhang J, Wei X,Gao L*. sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease. Immunogenetics. 2009;61(8):551-556.
BOOK CHAPTERS
1.Gao LF, the second editor-in-chief. iCourse of Medical Immunology. Higher education press,2016.
3.Gao LF, the first vice editor-in-chief. Key notes on Medical Immunology.People's Military Publishing House,2007.
4.Gao LF, the third editor-in-chief. Guide to Medical Immunology Test. Guangming Daily Press, 2004.
6.TEACHING COURSE
Medical Immunology for medical undergraduates and foreign students, PBL for medical undergraduates, Molecular Immunology and Cellular Immunology for master and doctoral students
7.CONTACT INFORMATION
The 6thBuilding,Room 6534
Department of Immunology
Schoolof Basic Medical Sciences, Shandong University
44# Wenhua Xi Road
Jinan, 250012, Shandong Province
P.R. China
Phone: 86-531-88382038,15562619322
E-mail:glfflg@sdu.edu.cn
