Xiaohong Liang Ph.D, Professor
Faculty Appointments:
2017.9 - Professor, Department of Immunology, Shandong University
2008.10 - 2017.8 Associate Professor, Department of Immunology, Shandong University
2012.12-2013.12 Visiting Scholars, University of Pennsylvania
2006.07 -2008.09 Assistant Professor, Department of Immunology, Shandong University
Major Teaching Responsibilities：
Immunology and Immunology Experiment for 5-year undergraduates, foreign students and graduate students.
Research fields：
1.Immunological mechanisms for liver diseases
2.Pathogenesis and immune therapy of liver cancer
Past and current grant：
1.TIPE1 inhibits the progression of non-alcohol fatty liver disease by sensing fatty acid signaling and maintaining the lipid metabolism, National Nature Scientific Foundation (81970508), 2020/01-2023/12,￥550,000.
2.HBV-enhanced Tim-3 promotes liver cancer by maintaining the function of tumor-initiating cells, National Nature Scientific Foundation (81672425), 2017/01-2020/12,￥570,000.
3.Novel death-regulation gene TIPE1 inhibits liver cancer by regulating small G-protein signaling pathway, National Nature Scientific Foundation (81372211), 2014/01-2017/12,￥750,000.
4.CUL4B promotes HBV replication by ubiquitinizing novel host proteins, National Nature Scientific Foundation (81171642), 2012/01-2015/12,￥600,000.
5.Roles of MicroRNA let-7a in HBV-related liver cancer, Fok Ying Tung Education Foundation (121038), 2010/05-2013/05, $20,000.
6.Roles of HBV core protein in liver cancer and its molecular mechanisms, National Nature Scientific Foundation (300700973), 2008/1-2010/12,￥16万0,000.
Published research paper（# first author，*corresponding author）：
1.Zhang H, Song Y, Yang H, Liu Z, Gao L,Liang X*, Ma C*. Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis. Oncogene. 2018 Feb 16. doi: 10.1038/s41388-018-0140-4.
2.Li X, Wang B, Gu L, Zhang J, Li X, Gao L, Ma C,Liang X*, Li X. Tim-3 expression predicts the abnormal innate immune status and poor prognosis of glioma patients.Clin Chim Acta. 2018 Jan;476:178-184.
3.Du J, Bai F, Zhao P, Li X, Li X, Gao L, Ma C,Liang X*. Hepatitis B core protein promotes liver cancer metastasis through miR-382-5p/DLC-1 axis. Biochim Biophys Acta. 2018;1865(1):1-11.
4.Wu Z, Tan S, Xu L, Gao L, Zhu H, Ma C,Liang X*.NgAgo-gDNA system efficiently suppresses hepatitis B virus replication through accelerating decay of pregenomic RNA. Antiviral Res. 2017 Jul 12;145:20-23.
5.Liu Y#, Xu Y, Ma H, Wang B, Xu L, Zhang H, Song X, Gao L,Liang X*, Ma C*.Hepatitis B virus X protein amplifies TGF-β promotion on HCC motility through down-regulating PPM1a. Oncotarget. 2016 May 31;7(22):33125-35.
6.Zhang Z#,Liang X#, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH, Ma C. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. Oncogene. 2015 May 14;34(20):2566-74.
7.Pan Y#, Wang B#, Yang X#, Bai F, Xu Q, Li X, Gao L, Ma C,Liang X*.CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.Sci Rep. 2015 Nov 23;5:17006.
8.Gai X#, Zhao P#, Pan Y, Shan H, Yue X, Du J, Zhang Z, Liu P, Ma H, Guo M, Yang X, Sun W, Gao L, Ma C,Liang X*.Hepatitis B virus core protein enhances human telomerase reverse transcriptase expression and hepatocellular carcinoma cell proliferation in a c-Ets2-dependent manner.Int J Biochem Cell Biol. 2013 Jul;45(7):1174-85.
9.Liu X#, You J#, Zhao D, Guo M, Pan Y, Gao L,Liang X*, Ma C*.Dysregulated expression of T cell immunoglobulin and mucin domain 3 is associated with the disease severity and the outcome of patients with spontaneous intracerebral hemorrhage.Clin Biochem. 2013 Oct;46(15):1502-8.
10.Du J#, Wang L#, Han J#, Gao L, Ma C,Liang X*. Serum soluble death receptor 5 concentration in patients with chronic hepatitis B is associated with liver damage and viral antigen level. Clin Biochem. 2012 Jul;45(10-11):845-7.
11.Juan Du#,Xiaohong Liang#,Yugang Liu, Zhonghua Qu, Lifen Gao, Lihui Han, Suxia Liu, Min Cui, Yongyu Shi, Zhiyong Zhang, Lijun Yu, Lili Cao, Chunhong Ma, Lining Zhang, Youhai Chen, Wensheng Sun. Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression. Cell death and differentiation. 2009 Feb;16(2):219-29.
12.Liang X#, Liu Y#, Zhang Q, Gao L, Han L, Ma C, Zhang L, Chen YH, Sun W. Human Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. Journal of Immunology, 2007; 178(1): 503-510.
13.Qu Z#,Liang X#,Liu Y, Du J, Liu S, Sun W. Hepatitis B virus sensitizes hepatocytes to complement-dependent cytotoxicity through downregulating CD59. Mol Immunol. 2009 Dec;47(2-3):283-9.
14.Liang X#, Qu Z#, Zhang Z, Du J, Liu Y, Cui M, Liu H, Gao L, Han L, Liu S, Cao L, Zhao P, Sun W. Blockade of preS2 down-regulates the apoptosis of HepG2.2.15 cells induced by TRAIL. Biochem Biophys Res Commun. 2008 May 2;369(2):456-63.
15.Xiaohong Liang#,Juan Du, Yugang Liu, Min Cui, Chunhong Ma, Lihui Han, Zhonghua Qu, Zhiyong Zhang, Zhaohui Sun, Lining Zhang, Youhai H. Chen, Wensheng Sun. The hepatitis B virus protein MHBs(t) sensitizes hepatoma cells to TRAIL-induced apoptosis through ERK2. Apoptosis, 2007; 12(10):1827–1836.
Memberships in Professional and Scientific Societies:
Member, Youth Committee of Shandong Society of Immunology
Office address:
Room 6534, Building 6th, Basic Medicine School of Shandong University
Office phone number:0531-88382038
E-mail：liangxiaohong@sdu.edu.cn
