Chunhong Ma, Ph.D.
1.RESEARCH INTERESTS
Dr. Ma’s field is immune regulation and gene regulation in liver diseases. The current research is focused on the following: 1) HBV induced immune dysfunction and related diseases. 2) Immune microenvironment in liver diseases, including CHB, HCC and NAFLD. 3) The action of Tim (T cell immunoglobulin domain and mucin domain containing molecule) family in innate and adaptive immunity.
2.PERSONAL DATA
Name: Chunhong Ma Sex: Female
Title: Professor Degree: Ph. D
Major: Immunology Date of Birth: January,1970 Nationality: Chinese Health: Excellent
3.EDUCATIONAL BACKGROUND AND PROFESSIONAL EXPERIENCE
1987-1991 B.S. Dept. of Biology, Shandong Normal University,China
1991-1994 M.S., Dept. of Biology, Huazhong Normal University,China
1999-2002 Ph.D., Shandong University School of Medicine,China
1994-2000 Lecture, Assistant Professor, Departments of Microbiology & Immunology, Shandong Medical University
2001-2003 Associate Professor, Departments of Immunology, Shandong University School of Medicine
2004-2005 Visiting Scholar, Departments of Microbiology & Immunology and Pathology & Laboratory Medicine, University of Kentucky Medical Center
2003- Professor, Departments of Immunology, Shandong University School of Medicine
2006-2016 Vice Dean, Shandong University School of Medicine Professor, Shandong University School of Medicine
2017.6- Director of Key Laboratory for Experimental Teratology of the Ministry of Education at Shandong University.
2018.2- Vice Dean, Shandong University Cheeloo College of Medicine
4.HONORS AND AWARDS
2003 Young Teacher Award in the Higher Education Institutions ofChina, Fok Ying-Tong Education Foundation
2009 Distinguished Young Scholar, Shandong Provincial Nature Science Foundation for in
2010 New Century Excellent Talents in University of Ministry of Education ofChina
2014 National Science Fund for Distinguished Young Scholars
2016 Gainer of The national youth talent support program
5.PUBLICATIONS AND BOOKS
SELECTED RESEARCH PAPERS
(*Corresponding author, **Co-corresponding author )
1.Yang H, Xie T, Li D, Du X, Wang T, Li C, Song X, Xu L, Yi F, Liang X, Gao L, Yang X,Ma C**. Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway[J]. Molecular Metabolism,2019,23 :24-36.
2.Zhang H,Song Y,Yang H,Liu Z,Gao L,Liang X,Ma C**. Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis. Oncogene. 2018; 37(18): 2456-2468.
3.Song X, Tan S, Wu Z, Xu L, Wang Z, Xu Y, Wang T, Gao C, Gong Y, Liang X, Gao L, Spear BT,Ma C**. HBV suppresses ZHX2 expression to promote proliferation of HCC through miR‐155 activation.Int J Cancer.2018;143(12) :3120-3130.
4.Xu L, Wu Z, Tan S, Wang Z, Lin Q, Li X, Song X, Liu Y, Song Y, Zhang J, Peng J, Gao L, Gong Y, Liang X, Zuo X,Ma C*. Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non-epigenetic manners. Antiviral Research.2018;153: 114-123.
5.Zhao D, Jiang X, Xu Y, Yang H, Gao D, Li X, Gao L,Ma C**, Liang X**.Decreased Siglec-9 Expression on Natural Killer Cell Subset Associated With Persistent HBV Replication. Front Immunol. 2018;9:1124.
6.Du X, Wu Z, Xu Y, Liu Y, Liu W, Wang T, Li C, Zhang C, Yi F, Gao L, Liang X,Ma C*. Increased Tim-3 expression alleviates liver injury by regulating macrophage activation in MCD-induced NASH mice. Cell Mol Immunol. 2018 May 7.
7.Xu L, Wu Z, Tan S, Wang Z, Lin Q, Li X, Song X, Liu Y, Song Y, Zhang J, Peng J, Gao L, Gong Y, Liang X, Zuo X,Ma C*. Tumor suppressor ZHX2 restricts hepatitis B virus replication via epigenetic and non-epigenetic manners. Antiviral Res. 2018;153:114-123.
8.Xu Y, Wang Z, Du X, Liu Y, Song X, Wang T, Tan S, Liang X, Gao L,Ma C*. Tim-3 blockade promotes iNKT cell function to inhibit HBV replication. J Cell Mol Med. J Cell Mol Med. 2018;22(6):3192-3201.
9.Zhang H, Song Y, Yang H, Liu Z, Gao L, Liang X**,Ma C**. Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis. Oncogene. 2018;37(18):2456-2468.
10.Zhao D, Guo M, Liu B, Lin Q, Xie T, Zhang Q, Jia X, Shu Q, Liang X, Gao L**,Ma C**. Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE. J Leukoc Biol. 2017;102(6):1313-1322.
11.Liu Y, Cheng Y, Xu Y, Wang Z, Du X, Li C, Peng J, Gao L, Liang X,Ma C*. Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers. Oncogene. 2017;36(44):6143-6153. doi: 10.1038/onc.2017.209.
12.Yan W, Liu X, Ma H, Zhang H, Song X, Gao L, Liang X,Ma C*. Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages.Gut. 2015;64(10):1593-604.
13.Zhang Z, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH**,Ma C**.TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. Oncogene. 2015;34(20):2566-74.
14.Luan F, Liu P, Ma H, Yue X, Liu J, Gao L, Liang X,Ma C*.Reduced nucleic ZHX2 involves in oncogenic activation of glypican 3 in human hepatocellular carcinoma. Int J Biochem Cell Biol. 2014;55C:129-135.
15.Zhang X, Gao L, Liang X, Guo M, Wang R, Pan Y, Liu P, Zhang F, Guo C, Zhu F, Qu C,Ma C*.HBV preS2 transcactivates FOXP3 expression in malignant hepatocytes. Liver Int. 2015;35(3):1087-94.
16.Zhuang X, Zhang X, Xia X, Zhang C, Liang X, Gao L, Zhang X,Ma C*. Ectopic Expression of TIM-3 in Lung Cancers. Am J Clin Pathol. 2012;137(6):978-85.
17.Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D, Liu X, Ma H, Guo M, Spear BT, Gong Y,Ma C*. Zinc Fingers and Homeoboxes 2 Inhibits Cell Proliferation and Represses Cyclin A and Cyclin E expression. Gastroenterology. 2012;142(7):1559-1570.e2.
18.Hou N, Zhao D, Liu Y, Gao L, Liang X, Liu X, Gai X, Zhang X, Zhu F, Ni M, Zhang Y, Sun W,Ma C*. Increased expression of T cell immunoglobulin- and mucin-domain-containing molecule-3 on NK cells in atherogenesis. Atherosclerosis. 2012;222(1):67-73.
19.Zhao D, Hou N, Cui M, Liu Y, Liang X, Zhuang X, Zhang Y, Zhang L, Yin D, Gao L, Zhang Y,Ma C*. Increased T cell Immunoglobulin and Mucin Domain 3 Positively Correlate with Systemic IL-17 and TNF-α Level in the Acute Phase of Ischemic Stroke. J Clin Immunol. 2011;31(4):719-27.
20.Liu Y, Shu Q, Gao L, Hou N, Zhao D, Liu X, Zhang X, Xu L, Yue X, Zhu F, Guo C, Liang X,Ma C*. Increased Tim-3 expression on peripheral lymphocytes from patients with rheumatoid arthritis negatively correlates with disease activity. Clin Immunol. 2010;137(2):288-95.
21.Liu H, Shi W, Luan F, Xu S, Yang F, Sun W, Liu J,Ma C*. Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase. Virus Genes. 2010;40(2):174-82.
22.Ju Y, Hou N, Meng J, Wang X, Zhang X, Zhao D, Liu Y, Zhu F, Zhang L, Sun W, Liang X, Gao L,Ma C*. T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B. J Hepatol. 2010;52(3):322-9.
23.Luan F, Liu H, Gao L, Liu J, Sun Z, Ju Y, Hou N, Guo C, Liang X, Zhang L, Sun W,Ma C *.Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT. Gut. 2009;58(11):1528-37.
BOOK CHAPTERS
Ma CH, the second editor-in-chief. Medical Immunology. Higher education press,2016.
6.TEACHING COURSE
Medical Immunology for medical undergraduates and foreign students, Molecular Immunology and Cellular Immunology for master and doctoral students
7.CONTACT INFORMATION
The 6thBuilding,Room 6436
Department of Immunology
Schoolof Basic Medical Sciences, Shandong University
44# Wenhua Xi Road
Jinan, 250012, Shandong Province
P.R. China
Phone: 86-531-88382038
E-mail:machunhong@sdu.edu.cn
