Yongyu Shi

Interest of research

Tumor immunology, mainly focusing on the relationship between macrophages and cancers, especially hepatocellular carcinomas, to explore the mechanisms of metastasis and immune evasion of cancers, as well as therapeutic strategies for treatment of cancers.

Personal introduction

Yongyu Shi, male, PhD, a professor in Department of Immunology, School of Basic Medical Science, Shandong University, #44,Wenhua Xi Road, Jinan 250012,China；a board member of Shandong Immunology Society; a chief investigator for the scientific research projects from NSFC and Department of Science and Technology of Shandong province ; a corresponding author of 11 SCI papers.

Educational background

1988.9-1993.7, Undergraduate, Qingdao Medical College

1995.7-1998.7，Master student, Shandong Academy of Medical Sciences

2001,9-2004.6，PhD student, Shandong University

2006.6-2006.12，Visiting scholar, California University, USA

2013.10-2014.10, Visiting scholar, Wisconsin University, USA

Representative publication

1. Zong Z, Zou J, Mao R, Ma C, Li N, Wang J, Wang X, Zhou H, Zhang L,Shi Y. M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1βSignaling. Front Immunol. 2019 Jul 16;10:1643.

2. Li N, Wang J, Zhang N, Zhuang M, Zong Z, Zou J, Li G, Wang X, Zhou H, Zhang L,Shi Y. Cross-talk between TNF-αand IFN-γsignaling in induction of B7-H1 expression in hepatocellular carcinoma cells. Cancer Immunol Immunother. 2018 Feb;67(2):271-283.

3. Zou J, Zhuang M, Yu X, Li N, Mao R, Wang Z, Wang J, Wang X, Zhou H, Zhang L,Shi Y. MYC inhibition increases PD-L1 expression induced by IFN-γin hepatocellular carcinoma cells. Mol Immunol. 2018 Sep;101:203-209.

4. Shi Y. Regulatory mechanisms of PD-L1 expression in cancer cells. Cancer Immunol Immunother. 2018 Oct;67(10):1481-1489.

5.Shi Y,Felder MA, Sondel PM, Rakhmilevich AL. Synergy of anti-CD40, CpG and MPL in activation of mouse macrophages. Mol Immunol. 2015 Aug; 66(2):208-15.

6. Wang H, Wang X, Li X, Fan Y, Li G, Guo C, Zhu F, Zhang L,Shi Y. CD68(+)HLA-DR(+) M1-like macrophages promote motility of HCC cells via NF-κB/FAK pathway. Cancer Lett. 2014 Apr; 345(1):91-9.

Teaching courses

Medical immunologyfor undergraduates;Cellular immunologyfor graduate students;Medial immunology experimentsfor undergraduates;Immunological experimental techniquesfor graduate students.

Contact

Office telephone: 88382038

Office Room 6536, Building 6, Baotu Spring, Shandong University.

Email address:shiyongyu@sdu.edu.cn