Xiaoyan Wang, M.D.
Department of Immunology,
School of Basic Medical Sciences,
Shandong University,
44# WenhuaXi Road, Jinan 250012, Shandong, P.R.China.
Cell phone number:86-13864096970
E-mail:wxy1970@sdu.edu.cn
Education
2006.10-2008.10 Postdoctor, Department of Gynecology, Qilu Hospital, Shandong University, Jinan City, Shandong Province
2004.06 M.D., Department of Immunology,School of Basic Medical Sciences, Shandong University, Jinan City, Shandong Province
1997.06 M.S., Department of Immunology, Weifang Medical College, Weifang city, Shandong Province
1992.06 B.S., Wannan Medical College, Wuhu City, Anhui Province
Work Experience
2011.01- Associate Professor, Department of Immunology,Schoolof Basic Medical Sciences, Shandong University
2009.12-2010.12 Visiting Scholar, Department ofExperimental Therapeutics, The University of Texas MD Anderson Cancer Center
2004.9-2009.12 Associate Professor, Department of Immunology,School of Basic Medical Sciences, Shandong University
1999.9-2004.8 Lecturer, Department of Immunology,School of Basic Medical Sciences, Shandong University
1997.7-1999.8 Assistant Teacher, Department of Immunology,Schoolof Basic Medical Sciences, Shandong University
Programs (From 2008 to 2018):
Principal Investigator
1.Project name: Study on the mechanism of TRIM27-regulating PDCD4 expression in ovarian cancer cells (2018-2021). NO: ZR2018MH013. Sponsored by: Natural Science Foundation of Shandong
2.Project name: Study on the effect and mechanism of PDCD4-regulating macrophage on proliferation and metastasis of ovarian cancer cells (2013-2017). NO: ZR2013HM105. Sponsored by: Natural Science Foundation of Shandong
3.Project name: Study on the effect and mechanism of tumor suppressor gene PDCD4 on LPS/D-GalN induced acute liver injury (2009-2012). NO: ZR2009CM013. Sponsored by: Natural Science Foundation of Shandong
4.Project name:Study on the effect of new tumor suppressor gene PDCD4 on chemosensitivity of ovarian cancer (2008-2010). NO:200802032. Sponsored by: Department of Personnel of Shandong
5.Project name: Study on the inhibitory effect of PDCD4 and Cisplatin on proliferation of ovarian cancer cells(2007-2009).NO:20070411096.Sponsored by: Ministry of Personnel ofChina
6.Project name: Study on the effect of Egfl7 on the formation of corneal neovascularization(2006-2008). NO:2006BS03064.Sponsored by: Department of Science and Technology of Shandong
Co-Investigator
1.Project name: Study on the effect of mechanism of TIPE2 on adenomyosis (2018-2021). NO: 81771554. Sponsored by: National Natural Science Foundation ofChina
2.Project name: Study on the effect and mechanism of tumor suppressor gene PDCD4 on endometriosis (2014-2018). NO:81471437. Sponsored by: National Natural Science Foundation ofChina
3.Project name: Study on the effect and mechanism of Epac1 on the proliferation and chemosensitivity of ovarian cancer cells (2012-2016). NO: ZR2012HM091. Sponsored by: Natural Science Foundation of Shandong
Selected Publications(From 2008 to 2018):
(*: First author；#：Corresponding author)
ØWang X*, Li Y*, Wan L, Liu Y, Sun Y, Liu Y, Shi Y, Zhang L, Zhou H, Wang J,Wang X#, Wei Z#. Downregulation of PDCD4 induced by progesterone is mediated by the PI3K/AKT signaling pathway in human endometrial cancer cells.Oncol Rep.2019; 42(2): 849-856.
ØLi Y*,Wang X*,Wang X, Wan L, Liu Y, Shi Y,Zhang L, Fang Z, Wei Z#. PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway.Biol Reprod.2018; 99(2): 360-372.
ØLiu Y*, Sun H*,Mao H, Gao M, Tan X, Li Y, Li Y, Muloye GM, Zhang L,Wang X#, Wei Z#. Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance. Oncol Lett. 2018; 15(6): 9369-9376.
ØSun Y*,Wang X*, Li Y, Sun H, Wan L, Wang X, Zhang L, Fang Z, Wei Z#. The decreased expression of TIPE2 protein in the decidua of patients with missed abortion and possible significance. Reprod Biol Endocrinol. 2017; 15(1):68-76.
ØLi Y*, Liu X*, Sun Y, Liu Y, Wan L, Zhang L, Fang Z, Wei Z#,Wang X#.The Expression of PDCD4 in Patients With Missed Abortion and Its Clinical Significance. Reprod Sci. 2017; 24(11):1512-1519.
ØWang L*, Zhao M, Guo C, Wang G, Zhu F, Wang J,Wang X,Wang Q, Zhao W, Shi Y, Chen YH, Zhang L#. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice. Inflamm Bowel Dis. 2016; 22(5): 1107-1118.
ØMa Y*, Wei Z*, Bast RC Jr, Wang Z, Li Y, Gao M, Liu Y, Wang X, Guo C, Zhang L,Wang X#.Downregulation of TRIM27 expression inhibits the proliferation of ovarian cancer cells in vitro and in vivo. Lab Invest. 2016; 96 (1): 37-48
ØGao M*, Ma Y*, Bast RC Jr, Li Y, Wan L, Liu Y, Sun Y, Fang Z, Zhang L,WangX#,Wei Z#.Epac1 knockdown inhibits the proliferation of ovarian cancer cells by inactivating AKT/Cyclin D1/CDK4 pathway in vitro and in vivo.Med Oncol. 2016; 33 (7):73-82
ØMeng Gao*, Wei Gao*, Zhanying Wang, Yanping Liu, Yue Li, Chao Wei, Yingshuo Sun, Chun Guo, Lining Zhang, Zengtao Wei#,Xiaoyan Wang#.The reduced PDCD5 protein is correlated with the degree of tumor differentiation in endometrioid endometrial carcinoma. Springplus. 2016; 5(1): 988-997
ØLiu Y*, Tan X*, Wang Z, Li Y, Gao M, Li Y, Fang Z, Sun Y, Zhang L,Wang X#,Wei Z#. Down-regulation of tumor suppressor PDCD4 expression in endometrium of adenomyosis patients. Curr Res Transl Med. 2016; 64(3): 123- 128.
ØLi Y*, Wang X*, Wei Z, Mao H, Gao M, Liu Y, Ma Y, Liu X, Guo C, Zhang L,Wang X#. Pretreatment with wortmannin alleviates lipopolysaccharide/D- galactosamine-induced acute liver injury. Biochem Biophys Res Commun. 2014; 455(3-4): 234-240.
ØMa Y*, Liu X*, Wei Z, Wang X, Xu D, Dai S, Li Y, Gao M, Ji C, Guo C, Zhang L,Wang X#. The expression of a novel anti-inflammatory cytokine IL-35 and its possible significance in childhood asthma. Immunol Lett. 2014; 162 (1 Pt A): 11-17.
ØMa Y*, Liu X*, Wei Z, Wang X, Wang Z, Zhong W, Li Y, Zhu F, Guo C, Zhang L,Wang X#. The expression and significance of TIPE2 in peripheral blood mononuclear cells from asthmatic children. Scand J Immunol. 2013; 78(6): 523-528.
ØSong X* Zhang X,Wang X, Zhu F, Guo C, Wang Q, Shi Y, Wang J, Chen Y, Zhang L#. Tumor suppressor gene PDCD4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene ATG5. Autophagy. 2013; 9(5): 743-755.
ØWang X*, Zhang L, Wei Z, Zhang X, Gao Q, Ma Y, Liu X, Jiang Y, Liu X, Guo C,Wang X#. The inhibitory action of PDCD4 in lipopolysaccharide/D- galactosamine-induced acute liver injury. Lab Invest. 2013; 93(3), 291-302.
ØZhang X*,Wang X*,Song X, Wei Z, Zhou C, Zhu F, Wang Q, Ma C, Zhang L#.Clinical and prognostic significance of lost or decreased PDCD5 expression in human epithelial ovarian carcinomas.Oncol Rep. 2011; 25(2):353-358.
ØAhmed AA,Wang X,Lu Z, Goldsmith J, Le XF, Grandjean G, Bartholomeusz G, Broom B, Bast RC Jr. Modulating microtubule stability enhances the cytotoxic response of cancer cells to Paclitaxel. Cancer Res. 2011;71(17):5806-5817.
ØZhang X*,Wang X*, Song X, Liu C, Shi Y, Wang Y, Afonja O, Ma C, Chen YH#, Zhang L#.Programmed cell death 4（PDCD4）enhances chemosensitivity of ovarian cancer cells by activating death receptor pathway in vitro and in vivo.Cancer Sci. 2010; 101 (10):2163-2170.
ØGao F*,Wang X*, Zhu F, Wang Q, Zhang X, Guo C, Zhou C, Ma C, Sun W, Chen Y#, Zhang L#. PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavorable prognosis. J Cell Mol Med. 2009; 13(10): 4257-4267.
ØWei ZT*, Zhang X*,Wang XY,Gao F, Zhou CJ, Zhu FL, Wang Q, Gao Q, Ma CH, Sun WS, Fu QZ, Chen YH#, Zhang LN#. PDCD4 inhibits the malignant phenotype of ovarian cancer cells.Cancer Sci.2009;100(8):1408-1413.
ØWang X*, Wei Z*, Gao F, Zhang X, Zhou C, Zhu F，Wang Q，Gao Q，Ma C, Sun W, Kong B, Zhang L. Expression and Prognostic Significance of PDCD4 in Human Epithelial Ovarian Carcinomas. Anticancer research. 2008; 28(5): 2991-2996.
