Lining Zhang M.D, Ph.D
Professor，Director,
Department of Immunology
School of Basic Medical Science,
Shandong University
44# Western Road, Jinan 250012, P.R. China
Tel: 86-531-88382038
E-mail: zhanglining@sdu.edu.cn
Lining Zhang, Ph.D.M.D,Professor, Director of Department of Immunology, School of Basic Medical Sciences, Shandong University. She is one of twentyMedical Talents of Shandong Provence andalso serves as the review expert of the National Science and Technology Awards and National Natural Science Foundation of China(NSFC),Presidentof the Shandong Society for Immunologyand vicechairmanof women Scientificworking committee in the Chinese Society for Immunology.Dr. Zhang’s research is to understand the cellular and molecular mechanisms whereby immune responses are regulated inmajor diseases.In recent years, her research focuses on exploring the role of new T cell subsets(Th17 and Treg) and new immune molecules（PDCD4 , TIPE2 and IL-37）in metabolism-related diseases (especial atherosclerosis and obesity) andcancer from animal models to clinical specimen.
Selected Publications
1.Li Y, Zhao M, Guo C, Chu H, Li W, Chen X, Wang X, Li Y, Jia Y, Koussatidjoa S, Zhu F, Wang J, Wang X, Wang Q, Zhao W, Shi Y, Chen W,Zhang L*.Intracellular matureIL-37suppresses tumor metastasis via inhibiting Rac1 activation.Oncogene. 2018 Feb 22;37(8):1095-110
2.Zhao M, Li Y, Guo C, Wang L, Chu H, Zhu F, Li Y, Wang X, Wang Q, Zhao W, Shi Y, Chen W,Zhang L*.IL-37isoform D downregulates pro-inflammatory cytokines expression in a Smad3-dependent manner.Cell Death Dis. 2018 May 22;9(6):582.
3.Wang L, Zhao M, Guo C, Wang G, Zhu F, Wang J, Wang X, Wang Q, Zhao W, Shi Y, Chen YH,Zhang L*.PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice.Inflamm Bowel Dis. 2016 May;22(5):1107-18
4.Wang L, Jiang Y, Song X, Guo C, Zhu F, Wang X, Wang Q, Shi Y, Wang J, Gao F, Zhao W, Chen YH, Zhang L*.Pdcd4deficiency enhances macrophage lipoautophagy and attenuates foam cell formation and atherosclerosis in mice.Cell Death Dis. 2016 Jan 21;7:e2055.
5.Jiang Y, Gao Q, Wang L, Guo C, Zhu F, Wang B, Wang Q, Gao F, Chen Y, Zhang L*.Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice.Cell Mol Immunol. 2016 Jul;13(4):524-34
6.Li Z, Guo C, Liu X, Zhou C, Zhu F, Wang X, Wang Q, Shi Y, Wang J, Zhao W, Zhang L*.TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression.Oncotarget.2016 Sep 20;7(38):62224-62239
7.Dai S, Wang B, Li W, Wang L, Song X, Guo C, Li Y, Liu F, Zhu F, Wang Q, Wang X, Shi Y, Wang J, Zhao WSystemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE-/-mice by modulating autophagy, foam cell formation and immune-negative molecules.
Cell Death Dis. 2016 Dec 1;7(12):e2498. doi: 10.1038/cddis.2016.376
8.Wang B, Dai S, Dong Z, Sun Y, Song X, Guo C, Zhu F, Wang Q, Zhang L.
The modulation of endoplasmic reticulum stress by chemical chaperone upregulates immune negative cytokineIL-35in apolipoprotein E-deficient mice.PLoS One. 2014 Jan 30;9(1):e87787.
9.Cao X, Zhang L, Shi Y, Sun Y, Dai S, Guo C, Zhu F, Wang Q, Wang J, Wang X, Chen YH, Zhang L*. Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1. Mol Cancer. 2013 Nov 26;12(1):149. doi: 10.1186/1476-4598-12-149.
10.Song X, Zhang X, Wang X, Zhu F, Guo C, Wang Q, Shi Y, Wang J, Chen Y, Zhang L*. Tumor suppressor gene Pdcd4 negatively regulates autophagy by inhibiting the expression of autophagy-related gene Atg5. Autophagy. 2013 May;9(5):743-55
11.Wang Q, Dong Z, Liu X, Song X, Song Q, Shang Q, Jiang Y, Guo C, Zhang L..PDCD4 Deficiency Prevents Diet-Induced Obesity, Adipose Tissue Inflammation and Insulin Resistance.Diabetes.2013 Dec;62(12):4132-43.
12.Wang X, Zhang L, Wei Z, Zhang X, Gao Q, Ma Y, Liu X, Jiang Y, Liu X, Guo C, Wang X. Lab Invest. 2013 Oct;93(10):1164.The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury.
13.Cao X,Zhang L,Shi Y,Sun Y,Dai S,Guo C,Zhu F,Wang Q,Wang J,Wang X,Chen YH, Zhang L .Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1.
Mol Cancer. 2013 Nov 26;12(1):149
14.Ma T, Gao Q, Zhu F, Guo C, Wang Q, Gao F, Zhang L.Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice.Cell Mol Immunol. 2013 Jul;10(4):338-48. doi: 10.1038/cmi.2013.4. Epub 2013 Apr 1.
15.Yael Gus-Brautbar, Derek Johnson, Li Zhang, Honghong Sun, Peng Wang, Shirley Zhang, Lining Zhang, and Youhai H. Chen. The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras.Mol Cell.2012 Mar 9;45(5):610-8.
16.Qi Gao,1*Yang Jiang1*，Tian Ma*, Faliang Zhu,*Fei Gao†，Pin Zhang,‡Chun Guo,*Qun Wang*,Xiaoyan Wang,*Chunhong Ma,*Yun Zhang,†Wanjun Chen2‡and Lining Zhang,2*A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice .J. Immunol.2010 Nov 15;185(10):5820-7. Epub 2010 Oct 15.
