Research Interest：Innate immunity, Antiviral immunity
Personal information:
Position |
Professor, Ph.D., M.D. |
|
Department of Immunology, School of Basic Medical Science, Shandong University, P. R. China |
Educational background and professional experience
•Professor,Department of Immunology, School of Basic Medical Science, Shandong University2013-present
•Lecture,Department of Immunology, Shandong University School of Medicine2011-2013
•Postdoc- Department of Immunology, Shandong University School of Medicine2008-2011
•Ph.D. –Institute of Immunology and National Key Laboratory of MedicalImmunology, Second Military Medical University--P.R.China2007 Supervisor:Xuetao Cao, Ph.D.
•B.S. –Clinical medicine-- Second Military Medical University--P.R.China2001
Selected Publications(*, corresponding author)
1. Zhao C#,Zhao W*. TANK-binding kinase 1 as a novel therapeutic target for viral diseases.Expert Opin Ther Targets.2019.23(5):437-446.
2. Li S, Liang X, Ma L, Shen L, Li T, Zheng L, Sun A, Shang W, Chen C,Zhao W*, Jia J*. MiR-22 sustains NLRP3 expression and attenuates H. pylori-induced gastric carcinogenesis.Oncogene.2018.37(7):884-896.
3.Yu Z#, Song H, Jia M, Zhang J, Wang W, Li Q, Zhang L,Zhao W*. USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.J.Exp.Med.2017.214(12):3553-3563.
4.Zhao C#, Jia M#, Song H, Yu Z, Wang W, Li Q, Zhang L,Zhao W*, Cao X*. The E3 ubiquitin ligase TRIM40 attenuates antiviral immune responses by targeting MDA5 and RIG-I.Cell. Rep. 2017.21(6):1613-1623.
5. Huai W#, Song H#, Yu Z, Wang W, Han L, Sakamoto T, Seiki M, Zhang L, Zhang Q,Zhao W*. Mint3 potentiates TLR3/4- and RIG-I-induced IFN-β expression and antiviral immune responses.Proc Natl Acad Sci USA.2016. 113(42):11925- 11930.
6. Song H#, Liu B#, Huai W#, Yu Z, Wang W, Zhao J, Han L, Jiang G, Zhang L, Gao C*,Zhao W*. The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3.Nat.Commun.2016. 7: 13727.
7. Song H#, Huai W, Yu Z, Wang W, Zhao J, Zhang L,Zhao W*.MLN4924, a first-in-class NEDD8-activating enzyme inhibitor, attenuates IFN-β production.J. Immunol.2016.196(7):3117-23.
8. Huai W#, Song H, Wang L, Li B, Zhao J, Han L, Gao C, Jiang G, Zhang L,Zhao W*. Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.J. Immunol.2015.194(9):4458-65.
9. Huai W#, Zhao R#, Song H, Zhao J, Zhang L, Zhang L, Gao C, Han L*,Zhao W*. Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription.Nat.Commun.2014. 5:4738.
10. Zhang M#, Wang L, Zhao X, Zhao K, Meng H,Zhao W*, Gao C*. TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.J.Exp.Med.2012. 209(10):1703-11.
Teaching courses：Medical Immunology, Molecular Immunology
E-mail：wzhao@sdu.edu.cn
