1. Personal Information
Name: |
Wenjuan Li |
Nationality: |
P. R. China |
|
Major: |
Medical Microbiology |
E-mail: |
wenjli@sdu.edu.cn |
Phone: |
0531-88382579 |
Address: |
Department of Microbiology, No.6 building Room 6504, School of Basic Medical Sciences, Shandong University 44 Wenhuaxi Road, Jinan, Shandong Province, P. R. China 250012 |
2. General Introduction
Wenjuan Li, Doctor of medicine, associate professor, deputy director of Department of Pathogeny Biology, Young member of the society of Microbiology and Immunology of Chinese Medical Association, Member of Bacteriology Subcommittee of Microbiology and Immunology Committee of Chinese Society for Microbiology. Member of Shandong Provincial Key Laboratory of Infection and Immunology. Member of the editorial board of the national appointed textbookMedical Microbiologyfor the medical students.
3. Education
2007.06-2008.07Joint training program for PhD students,Department of Medicine, Karolinska University Hospital Solna, Stockholm, Sweden
2003.09-2008.07Doctor of Medicine, Department of Microbiology, School of Medicine, Shandong University
1998.09-2003.6Bachelor ofClinical Medicine, School of Medicine, Qingdao University
4. Work Experience
2016.12-presentDeputy director of Department of Pathogeny Biology, School of basic medical sciences, Shandong University
2011.12-2016.11Associate Professor, Department of Microbiology, School of Medicine, Shandong University
2008.11-2011.11Postdoctor, Lecturer, Department of Microbiology, School of Medicine, Shandong University
5. Research area
(1)Gastric mucosal inflammation and carcinogenesis. We study aberrant signaling in gastric epithelial cells responding toHelicobacter pyloriinfection and we focus on dysregulation of epigenetic modification and non-coding RNAs in theH. pylori-mediated gastric carcinogenesis.
(2)We studynovel mechanism for the development of gastric cancer. We focused on genetic and epigenetic dysregulation of gastric cancer during its tumorigenesis and metastasis. We aim to find the early diagnostic markers and therapeutic targets of gastric cancer.
6. Funds
(1) Study on the role and molecular mechanism of a newly identified circRNA in the malignant transformation of gastric mucosa cells induced byHelicobacter pyloriinfection. Project of the National Natural Science Foundation of China, 2018.01-2021.12,PI
(2) Study on circRNAs as molecular diagnostic markers forHelicobacter pyloriassociated gastric cancer. the Key Research and Development Foundation of Shandong Province, 2018.01-2019.12,PI
(3) Study on the mechanism of histone demethylase JMJD2B regulating the invasion and metastasis of gastric cancer. Project of the National Natural Science Foundation of China, 2014.01-2017.12,PI
(4) The role of Reptin in gastric carcinogenesis by regulating telomerase activity. Project of the National Natural Science Foundation of China, 2011.01-2013.12,PI
(5) The molecular mechanism of Reptin regulating hTERT and promoting the development of gastric cancer. Doctoral fund of Ministry of Education of China, 2010.01-2012.12,PI
(6) Study on JMJD2B as a new anti-tumor target of gastric cancer. Postdoctoral Innovation Fund of Shandong Province, 2009.01-2010.12,PI
(7) Study on the molecular mechanism of Reptin in mediating the development of gastric cancer. Fund for Outstanding Young Scientist of Shandong Province, 2009.12-2012.12,PI
(8) The molecular mechanism ofHelicobacter pyloriin inducing senescence escape and epithelial-mesenchymal transition of gastric malignant transformation. Project of the National Natural Science Foundation of China, 2012.01-2015.12, Participant
(9) The mechanism of FoxM1 in regulating hTERT expression and mediating senescence escape of gastric cancer cells. Project of the National Natural Science Foundation of China, 2010.01-2012.12, Participant
7. Publications
1. Ma F, Li X, Ren J, Guo R, Li Y, Liu J, Sun Y, Liu Z, Jia J,Li W*. Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer. Cell Death Dis. 2019 Aug 19;10(9):623.
2. Jia W, Zhang J, Ma F, Hao S, Li X, Guo R, Gao Q, Sun Y, Jia J,Li W*. Long noncoding RNA THAP9-AS1 is induced by Helicobacter pylori and promotes cell growth and migration of gastric cancer. OncoTargets and Therapy. 2019:12 6653–6663
3. Zhang J, Ren J, Hao S, Ma F, Xin Y, Jia W, Sun Y, Liu Z, Yu H, Jia J,Li W*. MiRNA-491-5p inhibits cell proliferation, invasion and migration via targeting JMJD2B and serves as a potential biomarker in gastric cancer. Am J Transl Res. 2018 Feb 15;10(2):525-534.
4. Geng X, Li W, Chen Z, Gao S, Hong W, Ge X, Hou G, Hu Z, Zhou Y, Zeng B,Li W, Jia J, Sun Y. The Bifunctional Enzyme SpoT Is Involved in the Clarithromycin Tolerance of Helicobacter pylori by Upregulating the Transporters HP0939, HP1017, HP0497, and HP0471. Antimicrob Agents Chemother. 2017 Apr 24;61(5).
5. Han F, Ren J, Zhang J, Sun Y, Ma F, Liu Z, Yu H, Jia J,Li W*. JMJD2B is required for Helicobacter pylori-induced gastric carcinogenesis via regulating COX-2 expression. Oncotarget. 2016 Jun 21;7(25):38626-38637.
6. Ma L, Zeng J, Guo Q, Liang X, Shen L, Li S, Sun Y,Li W, Liu S, Yu H, Chen C, Jia J. Mutual amplification of HNF4α and IL-1R1 composes an inflammatory circuit in Helicobacter pylori associated gastric carcinogenesis. Oncotarget. 2016, 7(10):11349-63.
7. Liang X, Zeng J, Wang L, Shen L, Ma X, Li S, Wu Y, Ma L, Ci X, Guo Q, Jia M, Shen H, Sun Y, Liu Z, Liu S,Li W, Yu H, Chen C, Jia J. Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit. Oncotarget. 2015, 6(19):17661-74.
8. Yu H, Zeng J, Liang X, Wang W, Zhou Y, Sun Y, Liu S,Li W, Chen C, Jia J. Helicobacter pylori promotes epithelial-mesenchymal transition in gastric cancer by downregulating programmed cell death protein 4 (PDCD4). PLoS One. 2014, 9(8):e105306.
9. Zhao L*,Li W*, Zang W, Liu Z, Xu X, Yu H, Yang Q, Jia J. JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis. Clin Cancer Res. 2013 Dec 1;19(23):6419-29.
10. Feng Y, Wang L, Zeng J, Shen L, Liang X, Yu H, Liu S, Liu Z, Sun Y,Li W, Chen C, Jia J. FoxM1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by miR-370. Mol Cancer Res. 2013 Aug;11(8):834-44.
11. Yang Q, Wang B, Gao W, Huang S, Liu Z,Li W, Jia J. SIRT1 Is Downregulated in Gastric Cancer and Leads to G1-phase Arrest via NF-κB/Cyclin D1 Signaling. Mol Cancer Res. 2013 Dec;11(12):1497-507.
12. Liu Z, Li Q, Li K, Chen L,Li W, Hou M, Liu T, Yang J, Lindvall C, Björkholm M, Jia J, Xu D. Telomerase reverse transcriptase promotes epithelial–mesenchymal transition and stem cell-like traits in cancer cells. Oncogene 2013, 32(36):4203-13.
13. Ren J*,Li W*, Liu H, Yan L, Jiao W, Li D, Tang Y, Gu G, Xu Z. Overexpression of Reptin in renal cell carcinoma contributes to tumor malignancies and its inhibition triggers senescence of cancer cells. Urol Oncol. 2013 Oct;31(7):1358-66.
14. Liu Z, Xu X, Chen L,Li W, Sun Y, Zeng J, Yu H, Chen C, Jia J. Helicobacter pylori CagA Inhibits the Expression of Runx3 Via Src/MEK/ERK and p38 MAPK Pathways in Gastric Epithelial Cell. J Cell Biochem. 2012 Mar;113(3):1080-6.
15. Ren J*,Li W*, Yan L, Jiao W, Tian S, Li D, Tang Y, Gu G, Liu H, Xu Z. Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. Br J Cancer. 2011 Dec 6;105(12):1905-11.
16.Li W, Zhao L, Zang W, Liu Z, Chen L, Liu T, Xu D, Jia J. Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer. Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):372-8.
17. Wang H, Sun Y, Liu S, Yu H,Li W, Zeng J, Chen C, Jia J. Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration. FEMS Immunol Med Microbiol. 2011 Oct;63(1):82-92.
18. Qu W, Zhou Y, Sun Y, Fang M, Yu H,Li W, Liu Z, Zeng J, Chen C, Gao C, Jia J. Identification of S-nitrosylation of proteins of Helicobacter pylori in response to nitric oxide stress. J Microbiol. 2011 Apr;49(2):251-6.
19.Li W, Zeng J, Li Q, Zhao L, Liu T, Björkholm M, Jia J, Xu D. Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer. Mol Cancer. 2010 May 30;9:132.
20. Ge Z*,Li W*, Wang N, Liu C, Zhu Q, Björkholm M, Gruber A, Xu D. Chromatin remodeling: recruitment of histone demethylase RBP2 by Mad1 for transcriptional repression of a Myc target gene, telomerase reverse transcriptase. FASEB J. 2010; 24(2):579-86
21. Zhao D, Liu Z, Ding J,Li W, Sun Y, Yu H, Zhou Y, Zeng J, Chen C, Jia J. Helicobacter pylori CagA upregulation of CIP2A is dependent on Src and MEK/ERK pathways. J Med Microbiol. 2010 Mar;59(Pt 3):259-65.
22. Zeng J, Wang L, Li Q,Li W, Björkholm M, Jia J, Xu D. FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27kip1. Journal of Pathology. 2009 Aug;218(4):419-27.
23.Li W, Li L, Liu Z, Liu C, Liu Z, Strååt K, Björkholm M, Jia J, Xu D. Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. Cancer Letters. 2008,260, 28-36.
24.Li W, Ge Z, Liu C, Liu Z, Björkholm M, Jia J, Xu D. CIP2A Is Over-expressed in Gastric Cancer and Its Depletion Leads to Impaired Clonogenicity, Senescence or Differentiation of Tumor Cells. Clinical Cancer Research. 2008, 15; 14 (12):3722-8.
8. Teaching Courses
(1) Medical Microbiology (for undergraduate students)
(2) Medical Microbiology Experiments (for undergraduate students)
(3) PBL (for undergraduate students)
(4) Modern Microbiology (for graduate students)
(5) Molecular Bacteriology and Virology (for graduate students)
9. Awards
(1) Teaching competition for young teachers of Shandong University, the First Prize, 2016
(2) English teaching competition for young teachers of Shandong University, the First Prize, 2016
(3) National English teaching competition for young teachers in MBBS project, the Second Prize, 2016
(4) the 6thNational teaching competition for young teachers of medical colleges, the Third Prize, 2016
(5) The 6thand 8thTeaching Expert of Shandong University, 2012 and 2016
(6) Excellent doctorial dissertation of Shandong University, 2009
10. Member of Editorial Board
(1) Medical Microbiology, English version, Science Press, Member of editorial board, 2019
(2) Guidance and Exercises on Medical Microbiology, People's Health Publisher, Member of editorial board, 2018
(3) National medical education question bank, People's Health Publisher, Associate editor, 2017
(4) Medical Microbiology, China Medical Science and Technology Press, Member of editorial board, 2016
(5) Guidance and Exercises on Medical Microbiology, People's Health Publisher, Member of editorial board, 2016
(6) Experimental guidance of Medical Microbiology, People's Health Publisher, Member of editorial board, 2016
(7) Medical Microbiology, Digital textbook, People's Health Publisher, Member of editorial board, 2014
