Jihui Jia MD, Professor
BUSINESS ADDRESS
Shandong University
Cheeloo College of Medicine
No. 44 Wenhuaxi Road
Jinan, Shandong Province 250012 China
Tel.: 13853186075, 0531-88382672
E-mail:jiajihui@sdu.edu.cn
EDUCATION
1985 Bachelor of Medicine in Clinical Medicine Bengbu Medical College
1993 Master of Medicine in Microbiology and Immunology Bengbu Medical College
2003 MD in Microbiology Sun Yat-Sen University
PROFESSIONAL EXPERIENCE
Academic Positions at Shandong University
2015 – present Deputy Dean for Discipline and Education, Cheeloo College of Medicine
2012 – 2015 Dean, School of Nursing
2010 – 2012 Deputy Dean, College of Postgraduate Education
2008 – 2010 Party Secretary, School of Medicine
2004 – 2008 Associate Dean for Research, Discipline and Laboratories, School of Medicine
Other Appointments
2014 – present Director, Shandong University –Karolinska Institute Collaborative Laboratory onCancer Research
2013 – 2017 Director, World Health Organization Collaborating Centre for Nursing Care for Vulnerable Groups Including Those Impacted by Disasters
2008-2016 Director, Shandong Key Laboratory of Infection and Immunity
RESEARCH GRANTS
2012.01–2017.01 The National Major Scientific Program (Major 973)
“The role of telomere – related proteins in gene expression regulation and cell differentiation”
Role: Co – PI
2020.01 – 2023.12 General Program, National Natural Science Foundation
“The regulation mechanism of histone chaperone molecule ASF1B mediated the malignant transformation of helicobacter pylori infection”
Role: PI
2018.01 – 2021.12 General Program, National Natural Science Foundation (81772151)
“the regulatory mechanism of helicobacter pylori promoting the expression of pattern recognition receptor NLRP3 to mediate the transformation of inflammatory cancer”
Role: PI
2016.01 – 2017.12 International Joint Research Program (China/Sweden), National Natural Science Foundation
“Telomerase, tumor stem cells and tumor development/progress: strategies for tumor therapy targeting telomerase”
Role: PI
2016.01 – 2018.12 General Program, National Natural Science Foundation (81571960)
“Regulation mechanism of RNA binding protein LIN28A mediating the malignant transformation of helicobacter pylori infection”
Role: PI
2014.01 – 2016.12 General Program, National Natural Science Foundation (81371781)
“A Study on the pathogenic mechanism of network regulating node molecular HNF in the evolution of helicobacter pylori infection into malignant transformation”
Role: PI
2012.01 – 2015.12 General Program, National Natural Science Foundation (81171536)
“Molecular mechanism of helicobacter pylori inducing cell escape senescence and epithelial stromal transformation promoting malignant evolution”
Role: PI
2010.01 – 2013.12 General Program, National Natural Science Foundation (30972775)
“mechanism of FoxM1 regulating hTERT expression mediating escape senescence of gastric cancer cells”
Role: PI
2008.01 – 2011.12 General Program, National Natural Science Foundation (30770118)
“Molecular mechanism of helicobacter pylori CagA inhibiting Runx3 gene expression”
Role: PI
2003.01 – 2005.12 General Program, National Natural Science Foundation (30270079)
“Research on helicobacter pylori adaptive regulatory protein”
Role: PI
2018.01 – 2020.12 Major Scientific and Technological Innovation Project of Shandong Province (2018CXGC1208)
“Discovery of precise medical target for gastric cancer and individualized diagnosis and treatment”
Role: PI
SELECTED PUBLICATION(*corresponding or co-corresponding)
1.Zeng J, Ge Z, Wang L, Li Q, Wang N, Bjorkholm M,Jia J*, Xu d. The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells.Gastroenterology.2010 Mar;138(3):981-92. (latest impact factor 20.773, JCR Q1, SCI Q1)
2.Li W, Zeng J, Li Q, Zhao L, Liu T, Bjorkholm M,Jia J*, Xu d. Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer.Mol cancer.2010 May 30; 2. (latest impact factor 10.679, JCR Q1, SCI Q1)
3.Zhao L, Li W, Zang W, Liu Z, Xu X, Yu H, Yang Q,Jia J*. JMJD2B Promotes Epithelial and Mesenchymal Transition by Cooperating with beta Catenin and Enhances Gastric Cancer Metastasis.Clin Cancer Res,2013 Dec 1; 19(23):6419-29. (latest impact factor 8.911, JCR Q1, SCI Q1)
4.Li W, Ge Z, Liu C, Liu Z, Bjorkholm M,Jia J*, Xu d. CIP is overexpressed in gastric cancer and its depletion leads to spoilage, senescence, Or differentiation of tumor cells.Clin Cancer res.2008 Jun 15; 2A 14(12):3722-8. (latest impact factor 8.911, JCR Q1, SCI Q1)
5.Liu Z, Li Q, Li K,Chen L,Li W,Hou M,Liu T,Yang J,Lindvall C, Bjorkholm M,Jia J*, Xu d. Telomerase reverse transcriptase promotes epithelial and mesenchymal transition and stem cell - like traits in cancer cells.Oncogene.2013 Sep; 32(36):4203-4213. (latest impact factor 6.634, JCR Q1, SCI Q1)
6.Li S, Liang X, Ma L, Shen L, Li T, Zheng L, Sun A, Shang W, Chen C, Zhao W,Jia J*. MiR-22 sustains NLRP3 expression and attenuates H. pylori-induced gastric carcinogenesis.Oncogene.2018 Feb 15;37(7):884-896. (latest impact factor 6.634, JCR Q1, SCI Q1)
7.Li W, Li L, Liu Z, Liu C, Liu Z, Straat K, Bjorkholm M,Jia J*,Xu d. Expression of the full - length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues.Cancer Lett.2008 Feb 18; 260(1-2):28-36. (latest impact factor 6.508, JCR Q1, SCI Q1)
8.Zeng J, Wang L, Li Q, Li W, Bjorkholm M,Jia J*, Xu D. FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1.J Pathol.2009 Aug;218(4):419-27. (latest impact factor 5.942, JCR Q1, SCI Q1)
9.Zheng L, Liang X, Li S, Li T, Shang W, Ma L, Jia X, Shao W, Sun P, Chen C,Jia J* CHAF1A interacts with TCF4 to promote gastric carcinogenesis via upregulation of c - MYC and CCND1 expression.EBioMedicine.2018; Pii: s2352-3964 (18)30502-4. (latest impact factor 6.68, SCI Q1)
10.Li T, Shao W, Li S, Ma L, Zheng L, Shang W, Jia X, Sun P, Liang X,Jia J*. H. pylori infection induced BMAL1 expression and wrote disorder aggravate gastric inflammation.EBioMedicine.2018 Nov 27. Pii: S2352-3964 (18) 30547-4. (the latest impact factor of 6.68, SCI. Q1)
11.Liu T, Liang X, Li B, Bjorkholm M,Jia J*, Xu d. Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti - cancer effects.Br J cancer.2013 Jun 11. 108(11):2272-80. (latest impact factor 5.416)
12.Xu X, Zhang Y, Liu Z, Zhang X,Jia J*. miRNA-532-5p functions as an oncogenic microRNA in human gastric cancer by directly targeting RUNX3.J Cell Mol Med.2016 Jan; 20(1):95-103. (latest impact factor 4.658)
13.Feng Y, Wang L, Zeng J, Shen L, Liang X, Yu H, Liu S, Liu Z, Sun Y, Li W, Chen C,Jia J* Forkhead box M1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by hsa-miR-370.Mol Cancer Res.2013 Aug; 11(8):834-44. (latest impact factor 4.484)
14.Yang Q, Wang B, Gao W, Huang S, Liu Z, Li W,Jia J. SIRT1 Is Downregulated in Gastric Cancer and Leads to G1-phase Arrest via NF-κB/Cyclin D1 Signaling.Mol Cancer Res.2013Dec;11(12):1497-507 (latest impact factor 4.484)
15.Zhou Y, Wang G, Li Y, Liu Y, Song Y, Zheng W, Zhang N, Hu X, Yan S,Jia J*. In vitro interactions between aspirin and amphotericin B against fertilitonic cells and biofilm cells of Candida albicans and c. parapsilosis.Antimicrob Agents Chemother.2012 Jun; 56(6):3250-60. (latest impact factor 4.715)
16.Liu Z, Chen L, Zhang X, Xu X, Xing H, Zhang Y, Li W, Yu H, Zeng J,Jia J* RUNX3 regulates vimentin expression via miR-30 years during epithelial-mesenchymal transition in gastric cancer cells.J Cell Mol Med.2014 Apr; 18(4):610-23. (latest impact factor 4.658)
17.Li S, Sun A, Liang X, Ma L, Shen L, T, Li Zheng L, Shang W, Zhao W,Jia J*. Histone demethylase PHF8 promotes progression and metastasis of gastric cancer.Am J Cancer Res.2017 Mar 1; 7(3):448-461. (latest impact factor 4.737)
MEMBERSHIPS IN PROFESSIONAL & SCIENTIFIC SOCIETIES
(1) Standing Committee of the National Education and Research Union of Medical Colleges
(2) Committee of Tumor Molecular Medicine of Chinese Anti-Cancer Association
(3) Committee of Microbiology and Immunology of Chinese Medical Association.
(4) Honorary Director, Shandong Medical and Health Industry Association.
(5) Honorary Director, Internet and Medical Health Branch of Shandong Medical Association
(6) Chair, Committee of Microbiology and Immunology of Shandong Medical Association
(7) Director, Committee of Medical Microbiology of Shandong Microbiology Society
LECTURE COURSE
(1)Medical Microbiology
(2)Modern Medical Microbiology
