PERSONAL DATA
NAME: Yan Zhang
SEX: Female
BIRTH DATE: 12/10/1978
BIRTH PLACE:Taian, Shangdong Province
MARITAL STATUS: married
ADDRESS:Department of Pharmacology,
Schoolof Medicine,
ShandongUniversity,
44 West Wenhua Road, Jinan, Shandongprovince, 250012, P. R. China
Tel:+86-531-88382605 (office),
+86-15098817023 (cell)
E-mail:zhangyan1978@sdu.edu.cn
EDUCATION
September 2001 - July 2006
Ph.D major in immunology in School of Medicine, Shandong University, Jinan, Shandong Province,China.
September 1996 - July 2001
M.S major in Clinical Medicine in Taishan Medical College, Taian, Shandong Province,China.
WORKING EXPERIENCE
September 2013 -Present
Associated professor,
Department of Pharmacology, School of Medicine, Shandong University, Jinan,China.
July 2006 – August 2013
Assistant professor
Department of Pharmacology, School of Medicine, Shandong University, Jinan,China.
September 2010-September 2011
Visiting scholar
Department of pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
ACADEMIC ACTIVITIES AND MEMBERSHIP
2006— present
Member of Chinese Society of Pharmacology
GRANT SUPPORT
1. The role and mechanism of iRhom2 in hyperglycemia-induced podcyte injury. 2018.1-2021.12 National Nature Science Foundation. Project leader, No. 81770726
2. The role of iRhom2 in diabetic nephropathy through the regulation of endoplasmic reticulum stress. 2017.1-2018.12Department of science and technology in Shandong University. Project leader, NO. 2017GSF218095
3. The role and immunoregulation mechanism of TIPE2-Rac-NLRP3 signal network in cerebral ischemia reperfusion injury. 2014.1-2017.12 National Nature Science Foundation Project leader, No. 81371317
4. The role of TIPE2 in ischemia reperfusion injury. 2010.1-2012.12 National Nature Science Foundation. Project leader, No. 30901551
PUBLICATIONS
1. TIPE1 suppresses invasion and migration through down-regulating Wnt/β-catenin pathway in gastric cancer. Liu W, Chen Y, Xie H, Guo Y, Ren D, Li Y, Jing X, Li D, Wang X, Zhao M, Zhu T, Wang Z, Wei X, Gao F, Wang X, Liu S,Zhang Y(Co-corresponding author), Yi F. Cell. Mol. Med. Vol 22, No 2, 2018, 1103-1117J Cell Mol Med.2018 Feb;22(2):1103-1117.
2. Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk. Lin Z, Ge J, Wang Z, Ren J, Wang X, Xiong H, Gao J,Zhang Y(Co-corresponding author), Zhang Q. Sci Rep. 2017 Feb 14;7:42498.
3. Zhang H, Zhu T, Liu W, Qu X, Chen Y, Ren P, Wang Z, Wei X,Zhang Y(Co-corresponding author), Yi F.TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses in myocardial ischemia/reperfusion injury. J Mol Med (Berl). 2015 Sep; 93(9):1033-43.
4.Zhang Y, Wei X, Liu L, Liu S, Wang Z, Zhang B, Fan B, Yang F, Huang S, Jiang F, Chen YH, Yi F. TIPE2, a Novel Regulator of Immunity, Protects against Experimental Stroke. J Biol Chem. 2012, 287(39):32546-55.
5.Zhang Y, Qu ZH, Cui M, Guo C, Zhang XM, Ma CH, Sun WS*. Combined endostatin and TRAIL gene transfer suppresses human hepatocellular carcinoma growth and angiogenesis in nude mice. Cancer Biol Ther. 2009, 8(5):466-73. (IF: 3.33)
6.Zhang Y, Ma CH, Liu H, Zhang XM, Sun WS*. pVAX1 plasmid vector-mediated gene transfer of soluble TRAIL suppresses human hepatocellular carcinoma growth in nude mice. Acta Biochim Pol. 2007, 54(2):307-13. (IF: 1.395)
7. Zhang SY,Zhang Y(co-first author), Wei XB, Zhen JH, Wang ZY, Li MY, Miao W, Ding H, Du PC, Zhang WC, He M, Yi F*. Expression and regulation of a novel identified TNFAIP8 family is associated with diabetic nephropathy. Biochim Biophys Acta. 2010, 1802(11):1078-8681.
8. Fu YB,Zhang Y(co-first author), Wang ZY, Wang LL, Wei XB, Wen ZQ, Fang H, Pang Q, Yi F*. Regulation of NADPH Oxidase Activity Is Associated with miRNA-25-Mediated NOX4 Expression in Experimental Diabetic Nephropathy. Am J Nephrol. 2010, 32(6): 581-589.
9. Ruan Q, Kameswaran V,Zhang Y,Zheng S, Sun J, Wang J, DeVirgiliis J, Liou HC, Beg AA, Chen YH*. The Th17 immune response is controlled by the Rel-RORγ-RORγT transcriptional axis.. J Exp Med. 2011,208(11):2321-33. ( IF：14.102)
10. Wang ZY, Wei XB, Zhang Y, Ma XL, Li, BQ, Zhang SX, Du, PC, Zhang XM, Yi F*. NADPH oxidase-derived ROS contributes to upregulation of TRPC6 expression in puromycin aminonucleoside-induced podocyte injury. Cell Physiol Biochem 2009; 24:619-626（IF: 3.169）
