Xia Sun

RESEARCH INTERESTS

1. Study on the mechanisms of cancer development

2. Anti-tumor drug-screening and mechanism study

PERSONAL DATA

Birth date: November 29, 1976

Birth place: Feicheng City, Shandong province,China

EDUCATION

2006.09~2010.12 Ph.D. Department of pharmacology, School of Medicine,

Shandong University,China

2000.09~2003.07 M.S. Department of pharmacology, School of Medicine,

Shandong University,China

1994.09~1999.07 M.D. (equivalent) Taishan Medical School,China

ACADEMIC & PROFESSIONAL EXPERIENCE

2006.7~present Senior Lecturer, Department of pharmacology (cancer research), School of Medicine, Shandong University,China

2012.04~2013.04 Visiting scholar, Department of Gastroenterology, internal

medicine, University of Michigan, Ann Arbor, Michigan,USA

2003.07~2006.06 Teaching assistant, Department of pharmacology (cancer research), School of Medicine, Shandong University,China

PUBLICATIONS

1.Xia Sun, Min Liu, Ying Mao, Diming Zhao, Jianfeng Zhuang, Lei Liu. A novel tetrahydroisoquinoline (THIQ) analogue induces mitochondria-dependent apoptosis, Eur J Med Chem, 2018, 150:719-728

2.Xia Sun, Min Zhang, Mohamad El-Zataari, Gray B. Huffnagle, John Y. Kao, CCR2 mediatesHelicobacter pylori-induced immune tolerance and contributes to mucosal homeostasis, Helicobacter,2017, 22(2): doi: 10.1111/hel.12366

3.Xia Sun, Pier-Luc Clermont, Wenlin Jiao, Cheryl D. Helgason, Peter W. Gout, Yuzhuo Wang, Sifeng Qu, Elevated Expression of the Centromere Protein-A(CENP-A)-encoding Gene as a Prognostic and Predictive Biomarker in Human Cancers, International Journal of Cancer, 2016, 139(4):899-907

4.Xia Sun,MinZhang, Mohamad El-Zataari, Stephanie Y. Owyang, Kathryn A. Eaton, Maochang Liu, Yu-Ming Chang, Weiping Zou, John Y. Kao,TLR2 Mediates Helicobacter Pylori–induced Tolerogenic Immune Response in Mice, PLos One，2013, 8(9): e74595

5.Xia Sun, Xinbing Wei, Sifeng Qu, Yunxue Zhao, Xiumei Zhang*, Hydroxysafflor Yellow A Suppresses Thrombin Generation and Inflammatory Responses Following Focal Cerebral Ischemia-reperfusion in Rats, Bioorganic & Medicinal Chemistry Letters, 2010, 20(14):4120-4124

6. Sun Y, Zhang M, Chen CC, Gillilland M 3rd,Sun X, El-Zaatari M, Huffnagle GB, Young VB, Zhang J, Hong SC, Chang YM, Gumucio DL, Owyang C, Kao JY. Stress-Induced Corticotropin-Releasing Hormone-Mediated NLRP6 Inflammasome Inhibition and Transmissible Enteritis in Mice Gastroenterology. 2013,144(7): 1478-1487

7. Sifeng Qu, Jiani Wang, Xinbing Wei, Jianwei Zhang, Lixiang Wang, Lin Chen, andXia Sun*. Effects of losartan on the permeability of blood-brain barrier and the activity of MMP-9 on focal brain ischemia/reperfusion injury in rats. Journal of Shandong University (Health Sciences). 2007, 45(10): 992-995

8.Xia Sun, Xinbing Wei, Ru Sun, Lixiang Wang, Xuemei Li, and Xiumei Zhang. Anti-inflammatory effects of captopril on focal brain ischemia/reperfusion injury in rats. Chinese Journal of biochemical pharmaceutical, 2006, 27(1): 5-7

9.Xia Sun, Xinbing Wei, Ru Sun, Lixiang Wang, Xuemei Li, and Xiumei Zhang. Anti-inflammatory effects of losartan on focal brain ischemia/reperfusion injury in rats. Journal of Shandong University (Health Sciences), 2005,43(1): 997-1000

FUNDINGS

1.Sun Xia,et al. The role and mechanism of angiotensinⅡin thrombin-induced cerebral ischemia injury. The Science and Technique Foundation of Shandong Province, People’s Republic ofChina(2009GG10002035). 2009.08-2011.08. 1st

2.Sun Xia,et al. Studies of compound EXP-2528 on the mechanisms of angiotensinⅡ-induced expression of thrombin. Natural Science Foundation of Shandong Province, People’s Republic ofChina(ZR2010HQ057). 2010.11-2013.11. 1st

3.Sun Xia,et al. The role and mechanism of NLRP3-inflammasome in cerebral ischemia. Natural Science Foundation ofChina(81302770). 2014.01-2016.12. 1st

4.Sun Xia,et al. The role and mechanism of NLRP2-inflammasome in cerebral ischemia. Postdoctoral Science Foundation ofChina(2014M551917). 2014.5-2016.5. 1st

5.Sun Xia,et al. The role and mechanism of NLRP3-inflammasome activated by ROS in cerebral ischemia. Postdoctoral innovation project, Shandong(201402029). 2014.9-2016.9. 1st

6.Sun Xia,et al.Studies of the functional roles and mechanisms of CENPA-mediated epigenetic regulation on the progression and metastasis of breast cancer. Natural Science Foundation ofChina(81872894), 2019/01-2022/12. 1st

TEACHING COURSES

1.Pharmacology

2.Pharmacology Experiment

CONTACTS

Tel: 0531-88383146

E-mail: sunxia@sdu.edu.cn

Office number: 6204