NAME: Haiyan Lou
E-mail:louhaiyan@sdu.edu.cn
EDUCATION
September2002 - July 2005
Ph.D major in Cardiovascular Pharmacology in School of Medicine, Shandong University, Jinan,China.
September1997 - July 2000
M.S major in Pharmacologyin School of Pharmacy, Shandong University, Jinan,China
September1993 - July 1997
B.S major in Pharmacy in School of Pharmacy, Shandong University, Jinan,China
WORKING EXPERIENCE
July 2000 – present
Assistant professor, Associate professor
Department of Pharmacology, School of Medicine, Shandong University, Jinan,China.
September 2008 – September 2009
Postdoc training in University of Pittsburgh, Department of Neurology, Pittsburgh, PA,USA
FUNDINGS
1.The Nrf2/ARE pathway in modulating the protective effects of flavonoids against cerebral ischemia-reperfusion injury.The National Nature Science Fundation 2013.1-2016.12, No81274124,Principle Investigator, Fund: 700,000 RBM
2.The Nrf2/ARE pathway in modulating Parkinson’s disease and the protective effects of flavonoids from Dracocephalum.The National Nature Science Fundation 2013.1-2015.12, No81200982,Principle Investigator, Fund: 230,000 RBM
PUBLICATIONS
1. Shi H, Jing X, Wei X, Perez RG, Ren M, Zhang X,Lou H. S-allyl cysteine activates the Nrf2-dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo.J Neurochem.2014Nov 13. [Epub ahead of print].(Corresponding author)
2. Jing X, Shi H, Zhang C, Ren M, Han M, Wei X, Zhang X,Lou H. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity.Neuroscience.2014Nov 28. [Epub ahead of print].(Corresponding author)
3.Jing X, Ren D, Wei X, Shi H, Zhang X, Perez RG,Lou H, Lou H.Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury.Toxicol Appl Pharmacol.2013; 273(3):672-9.(Corresponding author)
4.Lou H, Jing X, Wei X, Shi H, Ren D, Zhang X. Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway.Neuropharmacology.2014; 79: 380-388
5. Han J, Wang M, Jing X, Shi H, Ren M,Lou H.(-)-Epigallocatechin Gallate protects against cerebral ischemia-induced oxidative stress via Nrf2/ARE signaling. Neurochem Res.2014, 39(7):1292-9.(Corresponding author)
6.Lou H, Jing X, Ren D, Wei X, Zhang X. Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway.Neurochem int.2012, 61,251-257
7. Wu J,Lou H,Alerte T, Stachowski E, Chen J, Singleton A, Hamilton R, Perez RG. Lewy-Like Aggregation Of Synuclein Reduces PP2A Activity In Vitro And In Vivo.Neuroscience.2012,207:288-97(Co-first author)
8.Lou H,Fan P, Perez RG, Lou H. Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death. Bioorg Med Chem2011, 19(13):4021-7
9.Lou H, Montoya SE, Alerte TN, Wang J, Wu J, Peng XM, Hong CS, Friedrich EE, Mader SA, Pedersen CJ, Marcus BS, McCormack AL, Di Monte DA, Daubner SC, Perez RG. Serine 129 phosphorylation reduces {alpha}-synuclein's ability to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo.J Biol Chem. 2010, 285(23):17648-61 (Co-first author)
10. Wang J,Lou H,Pedersen CJ, Smith AD, Perez RG. 14-3-3zeta contributes to tyrosine hydroxylase activity in MN9D cells: localization of dopamine regulatory proteins to mitochondria.J Biol Chem.2009, 284(21):14011-9. (Co-first author)
