1. RESEACH INTERESTS
Lei Li's group is interested in stem cell and development biology. Our main focus is the developmental processes of vascular-haematopoietic system during embryogenesis, such as vasculogenesis, angiogenesis and haematopoiesis, and how these processes are regulated in vivo using zebrafish as the model system. As a first author, Lei Li has published several high-impact papers in the past few years, including Blood, Nature Communications and Human Molecular Genetics. He has also participated in the publishing of several other papers, including Nature Genetics, International Journal of Biochemistry & Cell Biology, FEBS journal, FASEB Journal and PLoS ONE.
2. EDUCATION BACKGROUND AND PROFESSIONAL POSITIONS
Lei Li, graduated from Huazhong University of Science and Technology (HUST) with a PhD degree in Biochemistry and Molecular Biology in June 2013. After a year's postdoc work in the college of life science and technology, HUST, Lei Li joined the laboratories of Professor Roger Patient and Catherine Porcher in the MRC Weatherall Institute of Molecular Medicine (WIMM, University of Oxford) in January 2015. After four and a half years postdoctoral training in the UK, Lei Li joined the School of Basic Medical Sciences, Shandong University, as a Professor, supervisor of master and PhD student, and was awarded as "Cheeloo Young Scholars" in July 2019.
3. AWARDS AND HONORS
2019-2024“Cheeloo Youth Scholar”
2020-2025 Taishan Scholars Youth Project of Shandong Province
4. PUBLICATIONS:
(1)Lei Li, Rossella Rispoli, Roger Patient*, Aldo Ciau-Uitz* and Catherine Porcher*.Etv6 activatesvegfaexpression through positive and negative transcriptional regulatory networks inXenopusembryos.Nat Commun.2019 Mar 6;10(1):1083.
(2)Lei Li, Di Chen, Jia Li, Xiaojing Wang, Nan Wang, Chengqi Xu and Qing K. Wang*.Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish.Blood. 2014 Jan 23;123(4):501-8.
(3)Di Chen#,Lei Li#, Xin Tu, Zhan Yin* and Qing Wang*. Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis.Hum Mol Genet. 2013 Mar 1;22(5):963-76.
(4)Wang X, Li J, Yang Z, Wang L,Li L, Deng W, Zhou J, Wang L, Xu C, Chen Q, Wang QK*. Phlda3 overexpression impairs specification of hemangioblasts and vascular development.FEBS J. 2018 Nov;285(21):4071-4081.
(5) Li Wang, Xiaojing Wang, Longfei Wang, Muhammad Yousaf, Jia Li, Mengxia Zuo, Zhongcheng Yang, Dongzhi Gou, Binghao Bao,Lei Li, Ning Xiang, Haibo Jia, Chengqi Xu, Qiuyun Chen, and Qing Kenneth Wang*. Identification of a newadtrp1-tfpiregulatory axis for the specification of primitive myelopoiesis and definitive hematopoiesis.FASEB J. 2018 Jan;32(1):183-194.
(6)Zhenhong Su, Wenxia Si,Lei Li, Bisheng Zhou, Xiuchun Li, Yan Xu, Chengqi Xu, Haibo Jia and Qing K.Wang*. MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development.Int J Biochem Cell Biol. 2014 Apr;49:53-63.
(7) Lu Q, Yao Y, Yao Y, Liu S, Huang Y, Lu S, Bai Y, Zhou B, Xu Y,Li L, Wang N, Wang L, Zhang J, Cheng X, Qin G, Ma W, Xu C, Tu X* and Wang Q*. Angiogenic Factor AGGF1 Promotes Therapeutic Angiogenesis in a Mouse Limb Ischemia Model.PLoS One. 2012;7(10):e46998.
(8) F Wang, C Xu, Q He, JCai, X Li, D Wang, X Xiong, Y Liao, Q Zeng, Y Yang, X Cheng, C Li, R Yang, C Wang, G Wu, Q Lu, Y Bai, Y Huang, D Yin, Q Yang, X Wang, D Dai, R Zhang, J Wan, J Ren, S Li, Y Zhao, F Fu, Y Huang, Q Li, S Shi, N Lin, Z Pan, Y Li, B Yu, Y Wu, Y Ke, J Lei, N Wang, C Luo, L Ji, L Gao,L Li, H Liu, E Huang, J Cui, N Jia, X Ren, H Li, T Ke, X Zhang, J Liu, M Liu, H Xia, B Yang, L Shi, Y Xia, X Tu* and Q Wang*. Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population.Nat Genet. 2011 Mar 6;43(4):345-9.
5. TEACHING INFORMATION:
NONE.
6. CONTACT INFORMATION:
Email:leili1010@sdu.edu.cn
Telephone: +86-531-88381675
Office: Room 205, General Research Building, Cheeloo College of Medicine, Shandong University, No.44 Wenhua Xi Road, Ji'nan, Shandong
Laboratory: Room 6228,School of Basic Medical Sciences, Shandong University, No.44 Wenhua Xi Road, Ji'nan, Shandong
Post code: 250012, P.R.China
