Lin Chen, M.D. & Ph.D.
Associate Professor
Instituteof Pharmacology
Schoolof BasicMedical Sciences
ShandongUniversity
44# West Wenhua Road
Jinan, Shandong250012
P. R. China
Tel:86-0531-88382605(O)
86-15066154799(cell)
E-mail Adress:linchen@sdu.edu.cn
Birth Date:October 18, 1980
EDUCATION
School of Medicine, Shandong University, Jinan, P.R.China.
Ph. D. in Pharmacology, December 2009
Emphasis: cardiovascular pharmacology
School of Medicine, Shandong University, Jinan, P.R.China
M.D., June 2004
Emphasis: Clinical medicine
WORKING EXPERIENCE
September 2008 – October 2009
Visiting Scholar,
Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TNUSA.
January 2010 - August 2018
Assistant professor,
Instituteof Pharmacology, School of Medicine, Shandong University, Jinan, P.R.China.
September 2018 – Present
Associate Professor
FUNDINGS
1. The role and mechanism of NOD2/β-arrestin1/TRAF6 ubiquitination in cerebral ischemic injury, National Natural Science Foundation of China(No.81873748).
2.The role and mechanism of β-arrestin 2 in TLR9-mediated cerebral ischemia-reprfusion injury. National Natural Science Foundation ofChina(No.81100874).
3.The effect andpossible mechanism ofAngII/NOD2/TRAF signaling netin cerebral ischemia-reperfusion injury.ShandongProvinceNatural Science Foundation(No.ZR2017 MH010).
4.Theeffect and mechanism ofTLR9 in regulation IDO in cerebral ischemia-reperfusion injury.ShandongProvinceScience and Technology Plan (No.2018GSF118061).
Publications
1.Chen L, Kong L, Wei X, Wang Y, Wang B, Zhang X, Sun J, Liu H. β-arrestin 2 negatively regulates NOD2 signalling pathway through association with TRAF6 in microglia after cerebral ischaemia/reperfusion injury.J Cell Mol Med. 2019 Feb 22.
2.Ren Z,Chen L, Wang Y, Wei X, Zeng S, Zheng Y, Gao C, Liu H.Activation of the Omega-3 Fatty Acid Receptor GPR120 Protects against Focal Cerebral Ischemic Injury by Preventing Inflammation and Apoptosis in Mice.J Immunol. 2019; 202(3):747-759.
3.Cheng L,Chen L, Wei X, Wang Y, Ren Z, Zeng S, Zhang X, Wen H, Gao C,Liu H. NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.J Neuroinflammation. 2018; 15(1): 243.
4.Chen L, Ren Z, Wei X, Wang S, Wang Y, Cheng Y, Gao H, Liu H. Losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of Akt.Eur J Pharmacol.2017; 815: 98-108.
5.Chen L, Cheng L, Wei X, Yuan Z, Wu Y, Wang S, Ren Z, Liu X, Liu H.Tetramethylpyrazine Analogue CXC195 Protects Against Dopaminergic Neuronal Apoptosis via Activation of PI3K/Akt/GSK3β Signaling Pathway in 6-OHDA-Induced Parkinson's Disease Mice.Neurochem Res. 2017 Apr; 42(4):1141-1150.
6.Liu H, Wei X，Kong L, Cheng L, Yan S，Zhang X,Chen L*. NOD2 is involved in the inflammatory response after cerebral ischemia- reperfusion injury and triggers NADPH oxidase 2-derived reactive oxygen species.Int. J. Biol. Sci.2015; 11(5): 525-35.
7.Chen L, Wei X, Hou Y, Liu X, Li S, Sun B, Liu X, Liu H. Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia/reperfusion-induced apoptosis through PI3K/Akt/GSK3βpathway in rats.Neurochem Int.2014; 66: 27-32.
8.Chen L, Xiang Y, Kong L, Zhang X, Sun B, Wei X, Liu H. Hydroxysafflor Yellow A Protects Against Cerebral Ischemia-Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat.Neurochem Res.2013; 38(11):2268-75.
