Jie An
PERSONAL DATA
Name: Jie AN
Workplace: Department of Pharmacology, School of Basic Medical Science,
ShandongUniversity
Address: Rm 6204, Wenhuaxi Road 44#, Jinan city, Shandong province,China
Post Code: 250012
Tel: 0531-88383146
e-mail:anjie@sdu.edu.cn
RESEARCH INTERESTS
1. The pathophysiological andmolecular mechanisms of cerebral ischemia
2. Interactions between cells in pancreatic islets and the molecular mechanisms
EDUCATION
1993.9~1998.7 M.D.in Clinical Medicine, Taishan Medical College,China
1998.9~2001.7 M.S.in Physiology Huazhong Science and Technology University,China
2005.9~2008.12 Ph.D in Pharmacology
Instituteof Pharmacology, School of Medicine, Shandong University,China
PROFESSIONAL EXPERIENCE
2001.7~2004.7 Teaching Assistant
Institute of Pharmacology, School of Medicine, Shandong University
2004.7~2009.11 Assistant Professor
Institute of Pharmacology, School of Medicine, Shandong University
2009.12~present Associate Professor
Institute of Pharmacology, School of Medicine, Shandong University
2007.3 ~ 2008.9 visiting scholar Department of Neurology, Emory University,Atlanta,GA,USA
2011.11 ~ 2013.6 visiting scholar Department of Neurology, Emory University,Atlanta,GA,USA
Publications
1)An J,Haile WB, Wu F, Torre E, Yepes M. Tissue-type plasminogen activator mediates neuroglial coupling in the central nervous system.Neuroscience. 2014 Jan 17;257:41-8.
2) Sun X, Song X, Zhang L, Sun J, Wei X, Meng L,An J. NLRP2 is highly expressed in a mouse model of ischemic stroke. Biochem Biophys Res Commun. 2016 Oct 28;479(4):656-662.
3) Lu Y, An J, Liu Y, Ren L, Zhang L. MMP9 is involved in HO-1-mediated upregulation of apical junctional complex in Caco-2 cells under oxygen-glucose deprivation. Biochem Biophys Res Commun. 2018 Mar 25;498(1):125-131.
4）An J,Zhang C, Polavarapu R, Zhang X, Zhang X, Yepes M. Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain. Blood. 2008 Oct 1;112(7):2787-94.
5）Zhang C,An J,Strickland DK, Yepes M. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am J Pathol. 2009 Feb;174(2):586-94.
6）Zhang C,An J,Haile WB, Echeverry R, Strickland DK, Yepes M. Zhang C, An J, Haile WB, Echeverry R, Strickland DK, Yepes M. Zhang C, An J, Haile WB, Echeverry R, Strickland DK, Yepes M. Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain. JCereb Blood Flow Metab. 2009 Dec;29(12):1946-54.
7）Polavarapu R,An J,Zhang C, Yepes M. Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death. Am J Pathol. 2008 May;172(5):1355-62
8）Haile WB, Echeverry R, Wu F, Guzman J,An J,Wu J, Yepes M. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) and Fibroblast Growth Factor-Inducible 14 (Fn14) Mediate Cerebral Ischemia-Induced Poly(ADP-ribose) Polymerase-1 Activation and Neuronal Death. Neuroscience. 2010 Dec 29;171(4): 1256-64. Epub 2010 Oct 16.
9)Haile WB, Wu J, Echeverry R, Wu F,An J,Yepes M. Tissue-type plasminogen activator has a neuroprotective effect in the ischemic brain mediated by neuronal TNF-α. J Cereb Blood Flow Metab. 2012 Jan;32(1):57-69.
10) Bun Chan C, Liu X, Pradoldej S, Hao C,An J,Yepes M, Luo HR, Ye K. Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. J Neurosci. 2011 Jun 1;31(22):8083-92.
11) Wu F, Wu J, Nicholson AD, Echeverry R, Haile WB, Catano M,An J,Lee AK, Duong D, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Medcalf RL, Yepes M. Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain. J Neurosci. 2012 Jul 18;32(29):9848-58.
12）Wu F, Echeverry R, Wu J,An J,Haile WB, Cooper DS, Catano M, Yepes M. Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2-CREB-ATF3 signaling pathway. Mol Cell Neurosci. 2013 Jan; 52:9-19.
13）Wu F, Nicholson AD, Haile WB, Torre E,An J,Chen C, Lee AK, Duong DM, Dammer EB, Seyfried NT, Tong FC, Votaw JR, Yepes M. Tissue-type plasminogen activator mediates neuronal detection and adaptation to metabolic stress. 14) Sun H, Wen Y, Ning N, An J, Li J. Retinal toxicity associated with high dose of meclofenamic acid. J Cereb Blood Flow Metab. 2013 Jul 24. Drug Chem Toxicol. 2013 Oct;36(4):461-5.
15) Wu F, Catano M, Echeverry R, Torre E, Haile WB,An J,Chen C, Cheng L, Nicholson A, Tong FC, Park J, Yepes M. Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. J Neurosci. 2014 Oct 22;34(43):14219-32.
16）Wei X, Liu H, Sun X, Fu F, Zhang X, Wang J,An J, Ding H. Hydroxysafflor yellow A protects rats brain against ischemia-reperfusion injury by antioxidant action. Neuroscience Letters 386(2005)：58-62.
17)An J, CHEN Chang hua , GUAN Bing cai1 , TANG Ming , YU Cheng gao , LI Zhi wang. 5-HT2 receptor mediated the potentiation of GABA-activated current in the membrane of the dorsal root ganglion neurons of rat. Acta Pharmaceutica Sinica 2005, 40 (1) : 1–7
HORNERS
2010 Excellent Doctoral Dissertation of Shandong University
2010 First Prize of Youth Pharmacological Researcher in Second Session of Shandong Pharmacological Society
GRANTS
1.An Jie,et al. Effects of tPA Preconditioning on Cell Cycle Reentry-induced Neuronal Apoptosis. National Nature Science Foundation ofChina(NSFC 81173086 ) 2012.1~2015.12 Role: PI
2.An Jie,et al. Effects and Mechanisms of tPA and LRP1 on Neurovascular Unit of ischemic brain National Nature Science Foundation of China (NSFC 30900458 ) 2010.1~2012.12 Role: PI
3.An Jie,et al. The role and mechanism of AngⅡ-ATR-LRP1 signaling pathways in the formation of ischemic cerebral edema. Research Award Fund for Outstanding Young and Middle-aged Scientists in Shandong Province 2011BSE27053 2011.7-2014.7 Role: PI
4.An Jie,et al. Regulatory effect and mechanism of tPA on GluTs of neurovascular unit in cerebral ischemic penumbra.ChinaPostdoctoral Science Foundation 2015M570598 2015.6-2018.6 Role: PI
5.An Jie,et al. Regulatory effect and mechanism of tPA on energy metabolism of NVU in ischemic brain tissue through AMPK. Key research and development program in Shandong Province 2017GSF18138 2017.1-2018.12 Role: PI
TEACHING COURSES
1.Pharmacology
2.Pharmacology Experiment
