Huili Hu, Ph.D,Professor of Genetics
Telephone: 86-531-88382043
E-mail: huhuili@sdu.edu.cn
Education
2019-present Professor, School of Medicine, Shandong University
2014-2018 Lecture, School of Medicine, Shandong University
2016-2018 Postdoc, Hubrecht Institute Hans Clevers
2008-2014 PhD in Molecular Genetics and Epigenetics
School of Medicine, Shandong University,
2004-2008 B.S. in Biological Science,
State Key Laboratory of Microbial Technology,Shandong University
Awards/Honors
2018 Youth Science and technology talent promotion project in Shandong Province
2017 Future young scholars of Shandong University
2015 "Future scientist project" of the national scholarship committee
2014 one of 29 outstanding young researchers in Lindau Laureates meeting inChina
Research Interests：
Identification of liver specific stem / progenitor cell markers
mechanism of dedifferentiation and transdifferentiation of liver
organoids platform for drug screening
the application of multi cell type and new materials in tissue engineering of adult stem cells
Selected Publications（＊Correspondence）：
1.Huili Hu, Helmuth Gehart, Benedetta Artegiani, Carmen Lopez-Iglesias, Florijn Dekkers, Onur Basak, Johan van Es, Susana M. Chuva de Sousa Lopes, Harry Begthel, Jeroen Korving, Maaike van den Born, Chenhui Zou, Corrine Quirk, Luis Chiriboga, Charles M. Rice, Stephanie Ma, Anne Rios, Peter J. Peters, Ype P. de Jong, and Hans Clevers*. Long-term expansion of functional mouse and human hepatocytes as 3D organoids.Cell. 175, 1591–1606. 2018. (IF=36)
2.Huili Hu, Yang Yang, Qinghong Ji, Wei Zhao, Baichun Jiang, Ruiqiong Liu, Jupeng Yuan, Qiji Liu, Xi Li, Yongxin Zou, Changshun Shao, Yongfeng Shang, Yan Wang*, and Yaoqin Gong*. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.Cancer Cell. 22(6):781-795. 2012. (IF=23)
3.Fan Yang,Huili Hu,* Yuanyuan Liu, Ming Shao, Changshun Shao and Yaoqin Gong*. Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression. Cell Death and Disease 10:388.2019.
4.Benedetta Artegiani, Lisa van Voorthuijsen, Rik G.H. Lindeboom, Danielle Seinstra, Inha Heo,Pablo Tapia, Carmen Lo´ pez-Iglesias, Daniel Postrach, Talya Dayton, Rurika Oka,Huili Hu, Ruben van Boxtel, Johan H. van Es, Johan Offerhaus, Peter J. Peters, Jacco van Rheenen, Michiel Vermeulen, and Hans Clevers* Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.Cell Stem Cell24, 927–943.2019.
5.Johanna F. Dekkers, Maria Alieva, Lianne M. Wellens, Hendrikus C. R. Ariese,Paul R. Jamieson, Annelotte M. Vonk, Gimano D. Amatngalim,Huili Hu, Koen C. Oost,Hugo J. G. Snippert, Jeffrey M. Beekman, Ellen J. Wehrens, Jane E. Visvader, Hans Clevers* and Anne C. Rios* High-resolution 3D imaging of fixed and cleared organoids. Nature Protocols 2019.
6.Qing Li, Min Cui, Fan Yang, Na Li, Baichun Jiang, Zhen Yu, Daolai Zhang, Yijing Wang, Xibin Zhu,Huili Hu, Pei-Shan Li, Shang-Lei Ning, Si Wang, Haibo Qi, Hechen Song, Dongfang He, Amy Lin, Jingjing Zhang, Feng Liu, Jiajun Zhao, Ling Gao, Fan Yi, Tian Xue, Jin-Peng Sun, Yaoqin Gong, and Xiao Yu*. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest. 127(7): 2631–2646. 2017.
7.Jun Mi#, Yongxin Zou#, Xiaohua Lin, Juanjuan Lu, Xiaochen liu, Hui Zhao, Xiang Ye,Huili Hu, Baichun Jiang, Bo Han, Changshun Shao* and Yaoqin Gong. Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma. Mol Oncol. 11(3): 305–319. 2017.
8.Yanyan Qian, Junpeng Yuan,Huili Hu, Qifen Yang, Jishen Li, Shuqian Zhang, Baichun Jiang, Changshun Shao, Yaoqin Gong. The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment. Cancer Res. 75(23):5070-83. 2015.
9.Zhiliang Xu, Yeming Han, Jiying Liu, Fan Jiang,Huili Hu, Yan Wang, Qiji Liu, Yaoqin Gong, and Xi Li*. MiR-135b-5p and MiR-499a-3p Promote Cell Proliferation and Migration in Atherosclerosis by Directly Targeting MEF2C. Sci Rep. 2015; 5: 12276.
10.Wei Zhao, Baichun Jiang,Huili Hu, Shuqian Zhang, Shuaishuai Lv, Jupeng Yuan, Yanyan Qian, Yonxin Zou, Xi Li, Fang Liu, Changshun Shao and Yaoqin Gong*. Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Hum Mol Genet. 24(16):4686-97. 2015.
11.Xiaohan Zhao, Baichun Jiang,Huili Hu, Fei Mao, Jun Mi, Zhaohui Li, Qiji Liu, Changshun Shao and Yaoqin Gong*. Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression. Hum Mol Genet. 24(3):853-64. 2015.
12.Qinghong Ji,Huili Hu, Yang Fan, Junpeng Yuan, Yang Yang, Liangqian Jiang, Yanyan Qian, Baichun Jiang, Yongxin Zou, Yan Wang, Changshun Shao, and Yaoqin Gong*. CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression. J Cell Sci. 127(21):4679-91. 2014.
13.Junpeng Yuan, Han B,Huili Hu, Yanyan Qian, Zhaojian Liu, Zhao Wei, Xiaohong Liang, Baichun Jiang, Changshun Shao*, Yaoqin Gong*. CUL4B activates Wnt/β-catenin signaling in hepatocellular carcinoma by repressing Wnt antagonists.J Pathol. 28. doi: 10.1002/path.4492.2014.
14.Hu H,Yang Y, Ji Q, Zhao W, Jiang B, Liu R, Yuan J, Liu Q, Li X, Zou Y, Shao C, Shang Y, Wang Y, Gong Y* (2012). CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.Cancer Cell. 22(6):781-95. (IF=26.566)
15.JJi Q,Hu H, Ya ng F, Yuan J, Yang Y, Jiang L, Qian Y, Jiang B, Zou Y, Wang Y, Shao C, Gong Y*(2014). CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression.J Cell Sci. 127(21):4679-91. (IF=5.325)
16.Zhao X, Jiang B,Hu H, Mao F, Mi J, Li Z, Liu Q, Shao C*, Gong Y*(2014). Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression.Hum Mol Genet. 2014 Sep 30. pii: ddu503. [Epub ahead of print] (IF=6.677)
17.Yuan J, Han B,Hu H, Qian Y, Liu Z, Wei Z, Liang X, Jiang B, Shao C, Gong Y*(2014). CUL4B activates Wnt/β-catenin signaling in hepatocellular carcinoma by repressing Wnt antagonists.J Pathol.2014 Nov 28. doi: 10.1002/path.4492. [Epub ahead of print] (IF=7.33)
18.Guo H, Liu Z, Xu B,Hu H, Wei Z, Liu Q, Zhang X, Ding X, Wang Y, Zhao M, Gong Y, Shao C*(2013).Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage.Aging Cell. 12(6):1110-21. (IF=5.939)
19.Zou Y, Mi J, Wang W, Lu J, Zhao W, Liu Z,Hu H, Yang Y, Gao X, Jiang B, Shao C, Gong Y*(2013). CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.J Cell Biol. 200(6):743-56.IF=9.688)
20.Yang Y, Liu R, Qiu R, Zheng Y, Huang W,Hu H, Ji Q,He H, Shang Y, Gong Y, Wang Y*. CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing. Oncogene. (IF=8.559)
21.Lin P，Li J, Liu Q, Mao F, Li J, Qiu R,Hu H, Song Y, Yang Y, Gao G, Yan C, Yang W, Shao C, Gong Y* A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42).AJHG. 2008 Dec 12(83):752-59. (IF=10.987)
