Baichun Jiang, Ph.D, Associate Professor
Telephone: 86-531-88382080
E-mail: jiangbaichun@sdu.edu.cn
Education
2004.09-2010.06: |
Ph.D, Medical Genetics, School of Medicine, Shandong University |
2007.06-2008.05: |
Joint Ph.D student,Baylor College of Dentistry, Health Science Center, Texas A&M University |
2006. 06-2007.05: |
Joint Ph.D student, School of Dentistry, University of Missouri-Kansas City |
2000.09-2004.06: |
Bachelor, Biological Sciences, School of Life Sciences, Shandong University |
Appointments：
2017.09- present: |
Associate Professor, Department of Genetics, School of Basic Medical Sciences, Shandong University |
2010.07-2017.08: |
Lecturer, Department of Genetics, School of Medicine, Shandong University |
Research Interest：
Study the functions of disease-causing genes using transgenic and knockout mice models.
Selected Publications：
24. Xu Z, Li L, Qian Y, Song Y, Qin L, Duan Y, Wang M, Li P,Jiang B, Ma C, Shao C, Gong Y*. Upregulation of IL-6 in CUL4B-deficient myeloid-derived suppressive cells increases the aggressiveness of cancer cells.Oncogene. 2019, 38(30):5860-5872.
23. Kong Y*,Jiang B, Luo X. Gut microbiota influences Alzheimer's disease pathogenesis by regulating acetate in Drosophila model.Future Microbiol. 2018, 13:1117-1128.
22. Li Q#, Cui M#, Yang F#, Li N,Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Lin A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y*, Yu X*. A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.J Clin Invest. 2017, 127(7):2631-2646.
21. Mi J#, Zou Y#, Lin X, Lu J, Liu X, Zhao H, Ye X, Hu H,Jiang B, Han B, Shao C*, Gong Y*.Dysregulation of the miR-194-CUL4B negative feedback loop drives tumorigenesis in non-small-cell lung carcinoma.Mol Oncol. 2017, 11(3):305-319.
20. Liu P,Jiang B, Ma J, Lin P, Zhang Y, Shao C, Sun W*, Gong Y*.S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model.Dis Model Mech. 2017, 10(1):53-62.
19. Li P, Song Y, Zan W, Qin L, Han S,Jiang B, Dou H, Shao C, Gong Y*.Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity.Diabetes. 2017, 66(2):300-313.
18. Qian Y, Yuan J, Hu H, Yang Q, Li J, Zhang S,Jiang B, Shao C*, Gong Y*.The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment.Cancer Res. 2015, 75(23):5070-5083.
17. Zhao W#,Jiang B#, Hu H, Zhang S, Lv S, Yuan J, Qian Y, Zou Y, Li X, Jiang H, Liu F, Shao C*, Gong Y*.Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.Hum Mol Genet. 2015, 24(16):4686-4697.
16. Yuan J,Jiang B*, Zhang A, Qian Y, Tan H, Gao J, Shao C, Gong Y*.Accelerated hepatocellular carcinoma development in CUL4B transgenic mice.Oncotarget. 2015, 6(17):15209-15221.
15. Yuan J, Han B, Hu H, Qian Y, Liu Z, Wei Z, Liang X,Jiang B, Shao C, Gong Y*. CUL4B activates Wnt/β-catenin signaling in hepatocellular carcinoma by repressing Wnt antagonists.J Pathol.2015, 235(5):784-795.
14. Li J, Zhao X, Xin Q, Shan S,Jiang B, Jin Y, Yuan H, Dai P, Xiao R, Zhang Q, Xiao J, Shao C, Gong Y*, Liu Q*. Whole-Exome Sequencing Identifies a Variant in TMEM132E Causing Autosomal-Recessive Nonsyndromic Hearing Loss DFNB99.Hum Mutat. 2015, 36(1):98-105.
13. Zhao X,Jiang B, Hu H, Mao F, Mi J, Li Z, Liu Q, Shao C*, Gong Y*. Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression.Hum Mol Genet.2015, 24(3):853-864.
12. Ji Q, Hu H, Yang F, Yuan J, Yang Y, Jiang L, Qian Y,Jiang B, Zou Y, Wang Y, Shao C, Gong Y*. CRL4B interacts with and coordinates the SIN3A-HDAC complex to repress CDKN1A and drive cell cycle progression.J Cell Sci. 2014, 127(21):4679-4691.
11. Zou Y#, Mi J#, Wang W, Lu J, Zhao W, Liu Z, Hu H, Yang Y, Gao X,Jiang B, Shao C*, Gong Y*. CUL4B promotes replication licensing by up-regulating the CDK2-CDC6 cascade.J Cell Biol. 2013, 200(6):743-756.
10. He F#, Lu D#,Jiang B, Wang Y, Liu Q, Liu Q, Shao C, Li X*, Gong Y*. X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling.Biochim Biophys Acta. 2013, 1832(5):595-605.
9. Hu H, Yang Y, Ji Q, Zhao W,Jiang B, Liu R, Yuan J, Liu Q, Li X, Zou Y, Shao C, Shang Y, Wang Y*, Gong Y*. CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.Cancer Cell. 2012, 22(6):781-795.
8.Jiang B#, Zhao W#, Yuan J, Qian Y, Sun W, Zou Y, Guo C, Chen B, Shao C*, Gong Y*. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development.PLoS One. 2012, 7(5):e37070.
7. Cao Z,Jiang B, Xie Y, Liu CJ, Feng JQ*. GEP, a local growth factor, is critical for odontogenesis and amelogenesis.Int J Biol Sci. 2010, 6(7):719-729.
6.Jiang B#, Cao Z#, Lu Y, Janik C, Lauziere S, Xie Y, Poliard A, Qin C, Ward LM*, Feng JQ*. DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.J Bone Miner Res. 2010, 25(10):2155-2164.
5. Feng JQ#, Guo FJ#,Jiang BC, Zhang Y, Frenkel S, Wang DW, Tang W, Xie Y, Liu CJ*. Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.FASEB J. 2010, 24(6):1879-1892.
4. Li J, Yang Y,Jiang B, Zhang X, Zou Y, Gong Y*. Sp1 and KLF15 regulate basal transcription of the human LRP5 gene.BMC Genet. 2010, 11:12.
3. Lu X, Rios HF,Jiang B, Xing L, Kadlcek R, Greenfield EM, Luo G*, Feng JQ*. A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.Eur J Oral Sci. 2009, 117(6):625-635.
2. Feng JQ*, Scott G, Guo D,Jiang B, Harris M, Ward T, Ray M, Bonewald LF, Harris SE, Mishina Y*. Generation of a conditional null allele for Dmp1 in mouse.Genesis. 2008, 46(2):87-91.
1. Xia Y,Jiang B, Zou Y, Gao G, Shang L, Chen B, Liu Q, Gong Y*. Sp1 and CREB regulate basal transcription of the human SNF2L gene.Biochem Biophys Res Commun. 2008, 368(2):438-444.
