Name，Pei-Shan Li
Lecturer
Telephone:88382190
E-mail: lipeishan@sdu.edu.cn
Education and qualifications：
2003-2007 Bachelor of Engineering (B.E.), College of Life Science, Shandong University,
Jinan, Shandong,China
2007-2013 Ph.D., Institute of Biochemistry and Cell Biology, SIBS, CAS, Shanghai,China
Major in Biochemistry and Molecular Biology
Appointments：
2014.01-present：Lecturer, The Institute of Medical Genetics, School of Medicine, Shandong University
Research programme：the roles and mechanism of CUL4B in regulating adipocyte differentiation
Research Interest：
Obesity has been becoming a disease very harmful to our health in modern world. Among the many causes, abnormal adipocyte differentiation is a significant factor.
Previous studies have shown that mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with central obesity. However, the roles of CUL4B in obesity and lipid metabolism are totally unknown. Our studies showed that Cul4b deletion dramatically enhance adipogenic differentiation of mesenchymal stem cells. We believe that the function of CUL4B in adipocyte differentiation could explain the phenotype that CUL4B mutation causes obesity. To test this hypothesis, we will use Cul4b knock out mouse and in vitro adipocyte differentiation assay to investigate the roles and molecular mechanism of CUL4B in regulating adipocyte differentiation. This study will help us understand the incidence of obesity and provide new targets for obesity treatment.
Grants：
1. National Natural Science Foundation ofChina(Grant No. 81400841) 2015.1-2017.12
2.ChinaPostdoctoral Science Foundation (2014M561918)
3. Shandong Province Natural Science Foundation 2014.09-2017.09
Honours and awards:
2010, Young Scientist Award by the 17th East Asia Joint and 9th Cross-Strait Symposium on Biomedical Research
2013, Nationtional Graduate Scholarship
2014, Chinese Academy of Sciencer Dean Reward
2014, Excellent Graduate, Chinese Academy of Sciences
Key Publications:
1.Pei-shan Li, Yu Song, Wen-ying Zan, Li-ping Qin, Shuang Han, Bai-chun Jiang, Hao Dou, Chang-shun Shao and Yao-qin Gong* (2017). Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity.Diabetes66, 300-313 (IF: 8.784)
2.Pei-Shan Li, Zhen-Yan Fu, Ying-Yu Zhang, Jin-Hui Zhang, Chen-Qi Xu, Yi-Tong Ma, Bo-Liang Li and Bao-Liang Song (2014). The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.Nature Medicine20, 80–86(IF: 28.054)
3.Jian Wei#, Zhen-Yan Fu#,Pei-Shan Li#, Hong-Hua Miao, Bo-Liang Li, Yi-Tong Ma, Bao-Liang Song (2014). The Clathrin Adaptor Proteins ARH, Dab2, and Numb Play Distinct Roles in Niemann-Pick C1-Like 1 Versus Low Density Lipoprotein Receptor-mediated Cholesterol Uptake.The Journal of biological chemistry289, 33689-700 (IF: 4.863) (#Co-first author)
4.Tong-Fei Liu, Jing-Jie Tang,Pei-Shan Li, Yang Shen, Jia-Gui Li, Hong-Hua Miao, Bo-Liang Li and Bao-Liang Song (2012). Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.Cell Metabolism16, 213–225 (IF: 17.551)
5.Jing-Jie Tang, Jia-Gui Li, Wei Qi, Wen-Wei Qiu,Pei-Shan Li, Bo-Liang Li and Bao-Liang Song (2011). Inhibition of SREBP by a small molecule Betulin improves hyperlipidemia, insulin resistance and reduces atherosclerotic plaques.Cell Metabolism13, 44–56 (IF: 17.551)
