Name: Li Xi
Associate Professor
Telephone: 0531-88382190
E-mail: lixi@sdu.edu.cn
Education：
2006.05：Ph.D., Department of Biology and Biochemistry, University of Houston, TX,US
2001.07：B.S., Department of Microbiology, Shandong University, P.R. China
Appointments：
2008.09-present: Associate Professor, The Institute of Medical Genetics, School of Medicine, Shandong University
2006.09-2008.08: Lecture, The Institute of Medical Genetics, School of Medicine, Shandong University
Research Interests:
Cullin 4B is a scaffold protein that assembles cullin-RING ubiquitin ligase complexes. Recent studies have revealed that germ-line mutations inCUL4Bcan cause mental retardation, short stature and many other abnormalities in humans. Our studies focus on the separation and identification of specific CUL4B substrates and further understanding the pathogenesis caused by CUL4B-deficiency in humans.
Grants：(1) NSF ofChina(Grant No. 81271198,2013.1-2016.12);(2) NSF ofChina(Grant No. 81070223,2011.1-2013.12); (3) NSF ofChina(Grant No. 30800614,2009.1-2011.12)
Teaching Courses：
Medical Genetics for undergraduate students
Molecular Genetics for graduate students
Publications:
1. Han Y, Zhao S, Gong Y, Hou G, Li X*, Li L*. (2016) Serum cyclin-dependent kinase 9 is a potential biomarker of atherosclerotic inflammation. Oncotarget, 7(2):1854-1862 (IF=5.5)
2. Xu Z, Han Y, Liu J, Jiang F, Hu H, Wang Y, Liu Q, Gong Y, Li X*. (2015) MiR-135b-5p and miR-499a-3p promote cell proliferation and migration in atherosclerosis by directly targeting MEF2C. Sci Rep, 5: 12276 (IF=5)
3. Jiang W, Min J, Sui X, Qian Y, Liu Y, Liu Z, Zhou H,Li X*and Gong Y. (2014) MicroRNA-26a-5p and MicroRNA-23b-3p Upregulate Peroxiredoxin III in Acute Myeloid Leukemia,Leukemia and Lymphoma, Early Online (IF=2.6)
4. He F, Lu D, Jiang B, Wang Y,Liu Q, Liu Q, Shao C,Li X*, Gong Y*. (2012) X-linked intellectual disability gene CUL4B targets Jab1/CSN5 for degradation and regulates bone morphogenetic protein signaling,Biochim Biophys Acta, 1832(5):595-605. (IF=5)
5. Hu H, Yang Y, Ji Q, Zhao W, Jiang B, Liu R, Yuan J,Liu Q,Li X, Zou Y, Shao C, Shang Y, Wang Y*, Gong Y*. (2012)CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis,Cancer Cell, 22(6):781-795. (IF =26)
6.Li X, Lu D, He F, Zhou H, Liu Q, Wang Y, Shao C, Gong Y*. (2011) Cullin 4B Protein Ubiquitin Ligase Targets Peroxiredoxin III for Degradation,J Biol Chem, 286(37):32344-32354. (IF =5)
7.Li X,Tu SC*. (2006) Activity coupling ofVibrio harveyiluciferase and Flavin Reductase FRP: oxygen as a probe,Arch Biochem Biophys, 454 (1): 26-31. (IF=3)
8.Li X,Chow DC, Tu SC*. (2006)Thermodynamic analysis of the binding of oxidized and reduced FMN cofactor toVibrio harveyiNADPH-FMN oxidoreductase FRP apoenzyme,Biochemistry. 45 (49): 14781-14787. (IF =3)
