Qiji Liu, Ph.D, Professor
Telephone: 86-531-88382043
E-mail: liuqiji@sdu.edu.cn
Education
June 2005: PhD, Medical Genetics, Shandong University
June 2001: Master, Medical Genetics, Shandong Medical University
July 1991, Bachelor, Tongji Medical College HUST
Professional Experience
2007.9-present：Professor , Department of Genetics, Shandong University
2008.9-2009.8: Visiting Scholar, The University of Hong LKS Faculty of Medicine Kong
2004.9-2007.9: Associate Professor, Department of Genetics, Shandong University
2004.2-2005.2 Visiting Scholar, University of Kentucky School of Medicine
2001.7-2004.9: Lecturer, Department of Genetics, Shandong University
1991.7-1998.9: Instructor, Lecturer, Library, Shandong Medical University
Research Interests：
·Identifying the disease-causing mutation of rare Mendelian diseases using family dada through Next generation sequencing combined with SNP-based genome wide linkage analysis.
·Detection and functional analysis of rare genetic variants associated with systemic lupus erythematosus using population data through association study and In vivo, In vitro analysis.
Selected Publications（*Correspondence）：
1.Yuan Q, Li Y, Li J, Bian X, Long F, Duan R, Ma X, Gao F, Gao S, Wei S, Li X, Sun W, Liu Q*.WDFY4 Is Involved in Symptoms of Systemic Lupus Erythematosus by Modulating B Cell Fate via Noncanonical Autophagy.J Immunol. 2018 Nov 1;201(9):2570-257
2.Bian X, Lin P, Li J, Long F, Duan R, Yuan Q, Li Y, Gao F, Gao S, Wei S, Li X, Sun W, Gong Y, Yan C, Liu Q*. Whole-Genome Linkage Analysis with Whole-Exome Sequencing Identifies a Novel Frameshift Variant in NEFH in a Chinese Family with Charcot-Marie-Tooth 2: A Novel Variant in NEFH for Charcot-Marie-Tooth.Neurodegener Dis. 2018;18(2-3):74-83
3.Dang J, Bian X, Ma X, Li J, Long F, Shan S, Yuan Q, Xin Q, Li Y, Gao F, Gong Y, Liu Q. ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.J Immunol. 2017 Sep 1;199(5):1647-1659
4.Ma X, Qiu R, Dang J, Li J, Hu Q, Shan S, Xin Q, Pan W, Bian X, Yuan Q, Long F, Liu N, Li Y, Gao F, Zou C, Gong Y,Liu Q*. ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells.Sci Rep. 2015 Nov 25;5:17194
5.Li J,Zhao X,Xin Q,Shan S,Jiang B,Jin Y,Yuan H,Dai P,Xiao R,Zhang Q,Xiao J,Shao C, Gong Y,Liu Q*. (2014) Whole-exome Sequencing Identifies a Variant in TMEM132E Causing Autosomal-Recessive Nonsyndromic Hearing Loss DFNB99.Hum Mutat.36(1):98-105
6.Wang X, Xin Q, Li L, Li J, Zhang C, Qiu R, Qian C, Zhao H, Liu Y, Shan S, Dang J, Bian X, Shao C, Gong Y,Liu Q*. (2014) Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation.Eur J Hum Genet.22(9):1105-10[Medline]
7.Feng Y,Ke X,Zhai M,Xin Q,Gong Y,Liu Q*. (2013)Novel deletion of SPAST in a Chinese family with hereditary spastic paraplegia.SingaporeMed J.54(5):251-4
8.Qiu R, Yang Y, Zhao H, Li J, Xin Q, Shan S, Liu Y, Dang J, Yu X, Gong Y,Liu Q*. (2013)Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression.FEBS J.280(9):2014-26.
9.Xin Q, Li L, Li J, Qiu R, Guo C, Gong Y,Liu Q*. (2012)Eight-alanine duplication in homeobox D13 in a Chinese family with synpolydactyly.Gene.499(1):48-51.[Medline]
10.Wang X, Li L, Li J, Sun J, Heng X, Gong Y,Liu Q*. (2012)Pathogenic gene screening and mutation detection in a Chinese family with multiple osteochondroma.Genet Test Mol Biomarkers.16(7):827-32.[Medline]
11.Zou Y, Mi J, Cui J, Lu D, Zhang X, Guo C, Gao G,Liu Q,Chen B, Shao C, Gong Y. (2009) Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.J Biol Chem.284(48):33320-32[Medline]
12.Lin P, Li J,Liu Q, Mao F, Li J, Qiu R, Hu H, Song Y, Yang Y, Gao G, Yan C, Yang W, Shao C, Gong Y. (2008) A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42) .Am J Hum Genet.83(6):752-9.[Medline]
13.Zou Y,Liu Q,Chen B, Zhang X, Guo C, Zhou H, Li J, Gao G, Guo Y, Yan C, Wei J, Shao C, Gong Y. (2007) Mutation in CUL4B, a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation.Am J Hum Genet80: 561-566.[Medline]
14.Shan S, Dang J, Li J, Yang Z, Zhao H, Xin Q, Ma X, Liu Y, Bian X, Gong Y,Liu Q*.(2014)ETS1 variants confer susceptibility to ankylosing spondylitis in Han Chinese.Arthritis Res Ther.16(2):R87.[Medline]
15.Ma X, Liu Y, Zhang H, Qiu R, Zhao H, Xin Q, Shan S, Dang J, Li J, Yang Z, Gong Y,Liu Q*.(2014)Evidence for genetic association of CARD9 and SNAPC4 with ankylosing spondylitis in a Chinese Han population.J Rheumatol.41(2):318-24.[Medline]
16.Dang J, Shan S, Li J, Zhao H, Xin Q, Liu Y, Bian X,Liu Q*.(2014) Gene-gene Interactions of IRF5, STAT4, IKZF1 and ETS1 in systemic lupus erythematosus.Tissue Antigens.83(6):401-8[Mediline]
17.Qiu R, Zhang H, Zhao H, Li J, Guo C, Gong Y,Liu Q*.(2013)Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population.Scand J Rheumatol.42(6):469-72.
18.Liu Y, Zhang H, Li J, Zhao H, Xin Q, Shan S, Dang J, Bian X,Liu Q*. (2013)Association of common variants in KIF21B and ankylosing spondylitis in a Chinese Han population: a replication study.Immunogenetics.65(12):835-9.[Medline]
19.Zhao H, Yang W, Qiu R, Li J, Xin Q, Wang X, Feng Y, Shan S, Liu Y, Gong Y,Liu Q*.(2012)An intronic variant associated with systemic lupus erythematosus changes the binding affinity of Yinyang1 to downregulate WDFY4.Genes Immun.13(7):536-42.[Medline]
20.Fang Q, Zhao H, Wang A, Gong Y,Liu Q*.(2011) Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population.BMC Med Genet.12:133.[Medline]
21.Guo C, Xia Y, Yang Q, Qiu R, Zhao H,Liu Q*.(2012) Association of the ANTXR2 gene polymorphism and ankylosing spondylitis in Chinese Han.Scand J Rheumatol.41(1):29-32.[Medline]
22.Yang W, Shen N, Ye DQ,Liu Q,et al. (2010) Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus.PLoS Genet.6(2):e1000841[Medline]
23.Saadi A, Gao G, Li H, Wei C, Gong Y,Liu Q*. (2009) Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study.BMC Med Genet.10:71[Medline]
24.Liu Q,Xia Y, Zhang W, Li J, Wang P, Li H, Wei C, Gong Y. (2009)A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population.BMC Med Genet. 10:59.[Medline]
25.Liu QJ,Lin SS, Wang P, et al. (2007)A functional polymorphism of Tim-1 promoter region is associated with asthma in a Chinese population.Int Arch Allergy Immunol.,144:197-202.[Medline]
