NAME：Xiyu Zhang
Address:Department of Genetics,
School of Medicine, ShandongUniversity.
44#Wenhua Xi Road, Jinan, Shandong.
250012. P. R. China
Phone:(86) 531-88382190 (Office)
Email:xiyuzhang@sdu.edu.cn
EDUCATION/TRAINING
2006- 2012 Ph.D. in Medical and Molecular Genetics
ShandongUniversity, Jinan, P. R. China
1999-2002 M.S. in Medical Genetics
ShandongUniversity, Jinan, P. R. China
1995-1999 B.S. in Biochemistry
ShandongUniversity, Jinan, P. R. China
PROFESSIONAL EXPERIENCE
2015-present Associate Professor, Shandong University School of Medicine,
Jinan, Shandong
2004-2015 Lecture, Shandong University School of Medicine,
Jinan, Shandong
2002-2004 Assistant, Shandong University School of Medicine,
Jinan, Shandong
RESEARCH INTEREST
1. Senescence is defined as irreversible arrest of cell growth and loss of replicative capacity. Senescent cells have characteristic morphology (a large, flattened shape) and secretory phenotype. Accumulating evidence suggests that aberrant expression oflong non-coding RNAs(lncRNAs) play important roles incellular senescence. We found that hundreds of lncRNAs and mRNAs were differentially expressed inreplicatativesenescentand premature senescent human fibroblast cellscompared tonormal human fibroblast cells.
2.Neferine is a major alkaloid component in lotus embryos. We found that neferine possessed potent growth-inhibitory effect on human osteosarcoma cells, but not on non-neoplastic human osteoblasts cells. The inhibitory effect of neferine on human osteosarcoma cells was largelydue top38 MAPK-mediated p21 stabilization.
Grants
1.Functional and mechanistic study of the long non-coding RNA CAR intergenic 10 in cellular senescence.Project supported by the National Natural Science Foundation of China (Grant No.81401145).2015.1-2017.12.
2.Mechanistic study of neferine-initiated SIRT1 up-regulation and anti-aging effect.Shandong Province Foundation of outstanding Young Scientists (BS2013YY007). 2013.10-2015.10
PUBLICATIONS
1)Zhao M, Liu Q, Gong Y, Xu X, Zhang C, Liu X, Zhang C, Guo H,Zhang X, Gong Y, Shao C*. 2016. GSH-dependent antioxidant defense contributes to the acclimation of colon cancer cells to acidic microenvironment. Cell Cycle. 2016. 15:1125-1133
2)Zhang C, Hou D, Wei H, Zhao M, Yang L, Liu Q,Zhang X, Gong Y, Shao C*. Lack of interferon gamma receptor results in a microenvironment favorable for intestinal tumorigenesis. Oncotarget .2016. 7:42099-42109.
3)Guo H,Zhang X, Dong R, Liu X, Li Y, Lu S, Xu L, Wang Y, Wang X, Hou D, Wei J-J, Shao C and Liu Z. Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas . Oncotarget. 2014 Sep 30;5(18):8625-36.(co-first author)
4)Liu Z, Gersbach E,Zhang X, Xu X, Dong R, Lee P, Liu J, Kong B, Shao C, Wei JJ. miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma.Mol Cancer Res.2013 Nov;11(11):1314-25.
5)Guo H, Liu Z, Xu B, Hu H, Wei Z, Liu Q,Zhang X, Ding X, Wang Y, Zhao M, Gong Y, Shao C. Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage.Aging Cell.2013 Dec;12(6):1110-21.
6)Zhang, X., Z. Liu,B. Xu, Z. Sun, Y. Gong, and C. Shao. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization.European Journal of Pharmacology, 2012 Feb 29;677(1-3):47-54.(co-first author)
7)Li J, Yang Y, Jiang B,Zhang X, Zou Y, Gong Y. Sp1 and KLF15 regulate basal transcription of the human LRP5 gene.BMC Genet.2010 Feb 8;11(1):12.
8)Zou Y, Liu Q, Chen B,Zhang X, Guo C, Zhou H, Li J, Gao G, Guo Y, Yan C, Wei J, Shao C, Gong Y.Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation.Am J Hum Genet.2007 Mar; 80(3):561-6.
9)Zhang X,Liu Q, Chen B, Guo C, Li J, Gao G, Guo Y, Gong Y. A locus for nonspecific X-linked mental reatardation mapped to a 22.3 cM region of Xp11.3-q22.3.Am J Med Genet.2004,129A:286-289.
