Bo Su, Ph.D, Associate Professor, Master Instructor

Education：

2000.9-2005.7 Wuhan University, Microbiology, Ph.D

1996.9-2000.7 Wuhan University, Bachelor of Pharmacy

Research Experience:

2010.03-now Shandong University, School of Medicine，Associate Professor

2005.9-2010.01 Case Western Reserve University, Department of Pathology，Postdoc

Teaching

Undergraduate students teaching: "Cell Biology", "Cell Biology Experiment", "Human body

system II-Nervous System",

postgraduates teaching: ”Progress in Cell Biology", "Cell Biology Technology", "Medical

Neurobiology".

Research Interest：

Study on the pathogenesis of neurodegenerative diseases:

1) The role of abnormal mitochondrial homeostasis in neurodegenerative diseases.

Mitochondria, as important organelles in the cell, participate in a variety of cell

biological activities such as cell energy metabolism, Ca2+ balance regulation, and

apoptosis, and play a key role in maintaining the functions of tissues and organs.

Maintaining mitochondrial homeostasis is critical for the proper functions. The

abnormal mitochondria is found in many neurodegenerative diseases, but the

mechanism of mitochondrial abnormality is different in different diseases. We are

elucidat ing the mechanism of abnormal mi tochondr ial homeostasis in

neurodegenerative diseases and try to develop potential Drug therapy targets.

2) Research on molecular and cellular biological functions of genes related to neurological

diseases. There are many susceptible genes involved in nervous system diseases. To

study the role of these genes in the nervous system, especially their physiological and

pathological functions is very important for the treatment of diseases.

Scientific Research Project

1. National Natural Science Foundation ofChina，31571449，2016/01-2019/12，

716,000 RMB.

2．National Major Scientific Research Program，2012CB911004，2012/01-2016/08，

2,230,000 RMB.

3．National Natural Science Foundation of China Youth Fund Project，31100968，

2012/01-2014/12，250,000 RMB.

Published papers:

（1）Guo YY, Lu Y, Zheng Y, Chen XR, Dong JL, Yuan RR, Huang SH, Yu H, Wang Y, Chen ZY,

Su B*. Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory

via Its Deubiquitinating Effect on TrkB. J Neurosci. 2017, 37(25): 5978-5995

（2）Li Y, Wang D, Li Y, Chu H, Zhang L, Hou M, Jiang X, Chen Z, Su B*, Sun T*. Pre-synaptic

TrkB in basolateral amygdala neurons mediates BDNF signaling transmission in memory

extinction. Cell Death Dis. 2017; 8(7):e2959. (co-coresponding author)

（3）Zhang F#, Su B#, Wang C, Siedlak SL, Mondragon-Rodriguez S, Lee HG, Wang X, Perry G,

Zhu X*. Posttranslational modifications of α-tubulin in alzheimer disease. Transl Neurodegener.

2015, 4:9. (co-first author)

（4）Yan J, Liu XH, Han MZ, Wang YM, Sun XL, Yu N, Li T, Su B, Chen ZY*. Blockage of

GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of

Alzheimer's disease. Neurobiology of Aging; 2015, 36(1): 211-227.

（5）Wang W#, Zhang F#, Li L, Tang F, Siedlak SL, Fujioka H, Liu Y, Su B, Pi Y, Wang X*.

MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. J Biol

Chem. 2015, 290(1): 168-82.

（6）Su B#, Ji YS#, Sun XL, Liu XH, Chen ZY*. Brain-derived neurotrophic factor (BDNF)-

induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced

synaptic transmission. J Biol Chem. 2014; 289(3):1213-26. (共同第⼀作者)

Contact information：

Wenhua West Road 44#, Room 6604

Jinan City,

Shandong Province, China 250012

Email: bxs103@sdu.edu.cn

Tel: 0531-88382329