Xiaojing Wang, Ph.D

Associate professor

Department of Cell biology & Neurobiology

Schoolof BasicMedical Sciences

ShandongUniversity

Education

1992.9-1996.7 B.S. in Department of Biology, Shandong Normal University

1996.9-1999.7 Master in Zoology, Shandong Normal University

2001.9-2004.7 Ph.D. in Physiology, School of Medicine, Shandong University

Work Experience

2014.9-Present Associate Professor, Shandong University

2006.1-2009.2 Postdoctoral Research Fellow, University of Michigan and Indiana University,USA

2001.9-2014.8 Lecturer, Shandong University

1999.7-2001.9 Teaching Assistant, Shandong Medicine University

Research Areas

Neurorestoration and neurogenesis after focal cerebral ischemia in middle cerebral artery occlusion (MCAO) animal model. To study the migration, proliferation and differentiation of neural stem cells in the peri-infarct areas and new neurons how to survival and integrate into neural circuit.

Teaching

Attending the teaching to undergraduates(Cell Biology and Experiments of Cell Biology), graduate students (Progress in Cell Biology) and international students (Cell Dysfunction and Disease). Win several teaching awards and participates in some teaching reform projects. Compiled several textbooks.

Research Grants

1.The study of GDF11 on the neurogenesis in ischemic brain (2015GSF118020). Key Research and Development Plan of Shandong Province. 2015-2018.

2.The neuroprotection of Gypenosides on injured neural stem cells induced by alcohol. Natural Science Foundation of Shandong Province. 2017-2019.

3.The role of Beta-arrestin 2 regulates Shh pathway in the primary cilium of neural stem cells in hippocampus (81200951). National Natural Science Foundation ofChina. 2013-2015.

4.The role of chemokine receptor CXCR4 on the therapy of neural stem cells to glioblastoma (ZR2010HM002). Natural Science Foundation of Shandong Province. 2010-2013.

Selected Research Articles

1. Zhang, G., Wang, L., Liu, X., Zhang, Y., Hu, M., Liu, L., Fang, Y., Mu, Y., Zhao, Y., Huang, S., Liu, T.,Wang, X.Cerebral dopamine neurotrophic factor (CDNF) has neuroprotective effects against cerebral ischemia that may occur through the endoplasmic reticulum stress pathway.Int J Mol Sci. 2018 Jun 29;19(7).

2. Dong, L., Yang, K., Fu, W., Shang, Z., Zhang, Q., Jing, F., Li, L., Xin, H.,Wang, X.Gypenosides protected the neural stem cells in the subventricular zone of neonatal rats that were prenatally exposed to ethanol.Int J Mol Sci. 2014 Nov 28; 15(12): 21967-79.

3.Wang, X. *,Zhang, D. *, Xu, Z., Ma, M., Wang, W., Li, L., Han, X., Huo, Y., Yu, X., Sun, J.Understanding cadherin EGF LAG seven-pass G-type receptors.J Neurochem. 2014 Dec;131(6):699-711.

4.Wang, X., Sun, T., Kong, L., Shang, Z., Yang, K., Zhang, Q., Jing, F., Dong, L., Xu, X., Liu, J., Xin, H., Chen, Z.Gypenosides pre-treatment protects the brain against cerebral ischemia and increases neural stem cells/progenitors in the subventricular zone.Int J Dev Neurosci.2014 Apr;33:49-56.

5. Wang, Y., Kim E.,Wang, X.,Novitch, B., Yoshikawa, K., Chang, L., Zhu, Y. ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell, 2012, 150: 816-830.

6. Sun, T. *,Wang, X. *, Xie, S., Zhang, D., Wang, X., Li B., Ma, W. and Xin, H. A comparison of proliferative capacity and passaging potential between neural stem and progenitor cells in adherent and neurosphere cultures. Int J Devl Neuroscience, 2011, 29: 723-731.

7.Wang, X., Sinn, L., Pollok, K., Sandusky, G., Zhang S., Chen L., Liang, J., Zhang G., Crean, C., Suvannasankha, A., Abonour, R., Sidor, C., Bray, M., Farag S. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol, 2010, 150(3):313-25.

8.Wang, X.*, Hu, Jian.*, Zhao, D. *, Wang, G., Tan, L., Du L., Yang, J., Hou L., Zhang, H., Yu, Y., Zhang, H., Deng, H., Ding, M. NestinnegCD24low/- population from fetal Nestin-EGFP transgenic mice enriches the pancreatic endocrine progenitor cells. Pancreas, 2005, 31(4):385-391.

Contact Information

Schoolof Basic Medical Science, Shandong University

44 Wenhuaxi Road, Building 6, 6602 room

Jinan, Shandong Province,China

Tel: (531) 8838 2046

Email: luckingwang@sdu.edu.cn

Textbooks

1.Experiments of Cell Biology. Science Press. 2001.1. 2004. compiler

2.Modern technology of cell biology. Science Press. 2009.1.compiler

3.Practice of Medical Cellular and MolecularBiology.Science Press. 2018.6. Third section. compiler

4.Experimental guidance and exercise set of Medical Cell Biology. People’s medical publishing house. 2019.6. Fourth section. compiler