Zhaojian Liu Ph.D.

Professor of Cell Biology, Shandong University

Education

1999 B.S. Plant protection, Shandong agricultural University, China

2009 Ph.D. Medical and Molecular Genetics, Shandong University, China

Position and Employment

2017-Present Professor, Shandong University, China

2011-2017 Associated professor, Shandong University, China

2009-2011 Postdoctoral Research Fellow, Northwestern University. USA

2002-2009 Instructor and Lecturer, Shandong University, China

Research Interest

1. RNA Splicing in development and diseases

2. Non-coding RNA and cancer

Teaching

Undergraduates: Cell Biology, Experiments of Cell Biology

Graduate students: Progress in Cell Biology, Introduction to Biomedicine

Foreign students: Cell Dysfunction and Disease

Selected Publications (first or corresponding author)

1. Wang, Y., X. Zhang, W. Tang, Z. Lin, L. Xu, R. Dong, Y. Li, J. Li, Z. Zhang, X. Li, L. Zhao, J. J. Wei, C. Shao, B. Kong andZ. Liu(2017). "miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-kappaB in high-grade serous ovarian carcinoma." Cell Death Differ 24(12): 2089-2100.

2. Hou, D., G. Xu, C. Zhang, B. Li, J. Qin, X. Hao, Q. Liu, X. Zhang, J. Liu, J. Wei, Y. Gong,Z. Liuand C. Shao (2017). "Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition." Cell Death Dis 8(10): e3070.

3. Li, Y., H. Guo, C. Jin, C. Qiu, M. Gao, L. Zhang,Z. Liuand B. Kong (2017). "Spliceosome-associated factor CTNNBL1 promotes proliferation and invasion in ovarian cancer." Exp Cell Res 357(1): 124-134.

4. Li, Y., S. Lu, Y. Xu, C. Qiu, C. Jin, Y. Wang,Z. Liuand B. Kong (2017). "Overexpression of CD47 predicts poor prognosis and promotes cancer cell invasion in high-grade serous ovarian carcinoma." Am J Transl Res 9(6): 2901-2910.

5. Wei, L., X. Liu, W. Zhang, Y. Wei, Y. Li, Q. Zhang, R. Dong, J. S. Kwon,Z. Liu, W. Zheng and B. Kong (2016). "Overexpression and oncogenic function of HMGA2 in endometrial serous carcinogenesis." Am J Cancer Res 6(2): 249-259.

6.Liu, Z., E. Gersbach, X. Zhang, X. Xu, R. Dong, P. Lee, J. Liu, B. Kong, C. Shao and J. J. Wei (2013). "miR-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma." Mol Cancer Res 11(11): 1314-1325.

7.Liu, Z., J. Liu, M. F. Segura, C. Shao, P. Lee, Y. Gong, E. Hernando and J. J. Wei (2012). "MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma." J Pathol 228(2): 204-215.

8. Zhang, X.,Z. Liu, B. Xu, Z. Sun, Y. Gong and C. Shao (2012). "Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization." Eur J Pharmacol 677(1-3): 47-54.

9.Liu, Z., Q. Liu, B. Xu, J. Wu, C. Guo, F. Zhu, Q. Yang, G. Gao, Y. Gong and C. Shao (2009). "Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage." Mutat Res 662(1-2): 75-83.

Contact Information

Department of Cell Biology School of Medicine, Shandong University

Building No.6, Room No.6602

44 Wenhua Xi Road,Jinan, Shandong 250012, P.R.China

Tel: (531) 8838 2046

Email: liujian9782@sdu.edu.cn