Yue Xuetian
Ph.D., Professor
Department of Cell Biology, School of Basic Medical Science, Shandong University, 44 Wenhua Xi Road, Jinan 250012, China.
Email:yuexu@sdu.edu.cn
Research Areas
Tumor immunology, tumor metabolism, liver cancer
Education Background & Academic Experience
2018-Now Professor Department of Cell Biology, SBMS, Shandong University
2013-2018 Postdoc Rutgers Cancer Institute of New Jersey, Rutgers University
2009-2012 Ph.D. Department of Immunology, SBMS, Shandong University
2006-2009 Master Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech University
2001-2005 BS. Liaocheng University, Bioengineering
Selected Publications
1.Yue X,Zhang C, Zhao Y, Liu J, Lin AW, Tan VM, Drake JM, Liu L, Boateng MN, Li J, Feng Z*, Hu W*. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev. 2017 Aug 15;31(16):1641-1654. doi: 10.1101/gad.301564.117.
2.Yue X,Zhao Y, Xu Y, Zheng M, Feng Z*, Hu W*. Mutant p53 in cancer: Accumulation, gain-of-function and therapy. J Mol Biol. 2017 Apr 5. pii: S0022-2836(17)30163-8. doi: 10.1016/j.jmb.2017.03.030.
3.Yue X,Zhao Y, Huang G, Li J, Zhu J, Feng Z, Hu W*. A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell Discov. 2016 Nov 1;2:16039. eCollection 2016.
4.Yue X,Zhan Y, Zhang C, Li Jun, Liu Z, Liu J, Hu W*. LeLeukemia Inhibitory Factor Promotes EMT through STAT3-dependent miR-21 induction. Oncotarget .2016 Jan 26; 7(4):3777-90.
5.YueX,Zhao Y, Liu J, Zhang C, Yu H, Wang J, Zheng T, Liu L, Li J, Feng Z*, Hu W*. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. Elife. 2015. 4: e08401.
6.Yue X, Zhang Z, Liang X, Gao L, Zhang X, Zhao D, Liu X, Ma H, Guo M, Spear BT, Gong Y, Ma C*. Zinc fingers and homeoboxes 2 inhibits hepatocellular carcinoma cell proliferation and represses expression of Cyclins A and E. Gastroenterology. 2012. 142: 1559-1570.
7. Ma H,Yue X (co-first author), Gao L, Liang X, Yan W, Zhang Z, Shan H, Zhang H, Spear BT, Ma C*. ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA. Oncotarget. 2015. 6:1049-1063.
8.Liu J, Zhang C, Zhao Y,Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E, Haffty BG, Hu W*, Feng Z*.Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.Nat Commun. 2017 Nov 28;8(1):1823. doi: 10.1038/s41467-017-01947-w.
9. Zhang C, Liu J, Huang G, Zhao Y,Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W*, Feng Z*.Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016 Sep 1;30(17):1956-70.
10. Zhang C, Liu J, Zhao Y,Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W*, Feng Z*. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife. 2016 Jan 11; 5:e10727.
