Chunyuan Zhao, PhD, Research Assistant
Director and Under Secretary General for Shandong Society for Microbiology
Research Fields
Regulation of antiviral innate immune responses
With fighting against numerous pathogens infection for a long time, hosts have evolved the germline-encoded receptors, which termed as pattern recognition receptors (PRRs), to recognize invading pathogens, initiate innate immune responses and thus protect themselves. Different PRRs recognize multiple pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) derived from invading viruses, and then initiate innate antiviral signal transduction.The activation of antiviral innate immune responses should be tightly regulated to facilitate the elimination of viruses and maintain immune homeostasis. In our laboratory put emphasis on the multiple mechanisms associated with the regulation of antiviral innate immunity, such as posttranslational modification and epigenetic modification of critical adaptors in this signaling pathway.
Educational Background
2012.9-2017.7 Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, PhD.
2008.9 -2012.7 Science of biology, Marine College, Shandong University, B. S.
Papers published
Zhao, C., Jia, M., Song, H., Yu, Z., Wang, W., Li, Q., Zhang, L., Zhao, W. and Cao, X. (2017). “The E3 ubiquitin ligase TRIM40 attenuates antiviral immune responses by targeting MDA5 and RIG-I.” Cell Rep 21: 1613–1623.
Zhao, C., Zhao, W. (2019). “TANK-binding kinase 1 as a novel therapeutic target for viral diseases.” Expert Opin Ther Targets 23: 437-446.
Research Projects
The negative regulatory roles and molecular mechanisms of deubiquitinase USP36 in antiviral innate immune responses. National Natural Science Foundation of China (Youth Program), 220 thousand yuan, 2020-2022.
Courses
Cell Biology, Experiment of Cell Biology
Contact Information
Office number: 6602
Office telephone number: 0531-88382046
e-mail: cyzhao@sdu.edu.cn
